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2003 (Engelska)Ingår i: European Journal of Nutrition, ISSN 1436-6207, E-ISSN 1436-6215, Vol. 42, nr 2, s. 2748-2755Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
Background: Night work is becoming more common and shift workers display several metabolic disturbances. Aim: To study the endocrine responses in relation to time of day during a 24-h period and how dietary macronutrient composition affects these responses. Design: Seven males (26-43 y and 19.9-26.6 kg · m-2) were studied in a crossover design. Isocaloric diets described as highcarbohydrates (HC; 65 energy percent (E%) carbohydrates and 20E% fat) or high-fat (HF; 40E% carbohydrates and 45E% fat) were given. After a 6-day diet adjustment period, the subjects were kept awake for 24 h in a metabolic unit and were served an isocaloric meal (continuation of respective diet) every 4-h. Blood samples were taken throughout the 24-h period. Results: Insulin and leptin responses to meal intake differed with respect to time of day (p ≤ 0.05). Time of day affected glucagon, thyroid stimulating hormone (TSH), free thyroxin (fT4), total triiodothyronine (tT3), cortisol, chromogranin A (CgA) and pancreatic polypeptide (PP) concentrations (p ≤ 0.05). Meal intake decreased cortisol concentration after meals at 0800, 1200 and 0400 but not at 1600, 2000 and 0000 h. The PP's postprandial increase was greater during 0800-1600 h compared to 2000-0800 h. With the HC meals, lower glucagon and CgA concentrations (p ≤ 0.05), and a tendency for lower tT3 concentrations (p = 0.053) were observed compared to the HF meals. Conclusion: Insulin, PP, TSH, fT4, cortisol and leptin responses to meal intake differed with respect to time of day. The decreased evening/nocturnal responses of cortisol and PP to meal intake indicate that nocturnal eating and night work might have health implications.
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Identifikatorer
urn:nbn:se:ltu:diva-6676 (URN)10.1007/s00394-003-0386-6 (DOI)000182209000001 ()12638028 (PubMedID)2-s2.0-0242668303 (Scopus ID)4efcfdb2-d5cd-4be7-aa54-ac737d43caa5 (Lokalt ID)4efcfdb2-d5cd-4be7-aa54-ac737d43caa5 (Arkivnummer)4efcfdb2-d5cd-4be7-aa54-ac737d43caa5 (OAI)
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Upprättat; 2003; 20151204 (andbra)2016-09-292016-09-292023-05-08Bibliografiskt granskad