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Publications (10 of 248) Show all publications
Vedung, F., Hänni, S., Tegner, Y., Johansson, J. & Marklund, N. (2020). Concussion incidence and recovery in Swedish elite soccer: prolonged recovery in female players. Scandinavian Journal of Medicine and Science in Sports, 30(5), 947-957
Open this publication in new window or tab >>Concussion incidence and recovery in Swedish elite soccer: prolonged recovery in female players
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2020 (English)In: Scandinavian Journal of Medicine and Science in Sports, ISSN 0905-7188, E-ISSN 1600-0838, Vol. 30, no 5, p. 947-957Article in journal (Refereed) Published
Abstract [en]

Objectives

Sport‐related concussions are an increasingly recognized health problem. Soccer is the most popular sport in the world although recent studies on concussion incidence are scarce. Here, a nation‐wide prospective study on concussion incidence, symptom severity, risk factors, gender differences and return‐to‐play after concussion was performed in 51 Swedish elite soccer teams during the 2017 season.

Methods

In the first and second soccer leagues for men and women, a Sport Concussion Assessment Tool (SCAT) ‐based questionnaire study was performed at pre‐season (baseline) and from 48h up to three months post‐concussion.

Results

We followed 959 players (389 women, 570 men) for 25146 player game hours (9867 h for women, 15279 h for men). Concussion incidence (n= 36) was 1.19/1000 player game hours (females 1.22/1000 h, males 1.18/1000 h; p= 0.85). Twenty‐seven percent (females 8%, males 40%) of players continued to play immediately after the concussion. When compared to male players, female players had worse initial symptom severity scores (median and IQR 30 (17‐50.5) vs. 11 (4‐26.25), p=0.02) and longer return to play (p=0.02). Risk factors for concussion were baseline symptoms and previous concussion.

Conclusion

In Swedish elite soccer, the concussion incidence was 1.19/1000 without gender differences. Most players recovered to play within four weeks post‐injury. Almost one third of players continued to play at time of concussion. Female players had worse initial symptoms and longer return‐to‐play time than males, and a prolonged recovery beyond three months was only observed among female players.

Place, publisher, year, edition, pages
John Wiley & Sons, 2020
Keywords
female, questionnaire, return-to-play, soccer, Sports Concussion Assessment Tool (SCAT), sports-related concussion
National Category
Medical and Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-77957 (URN)10.1111/sms.13644 (DOI)32100894 (PubMedID)2-s2.0-85081752661 (Scopus ID)
Funder
Swedish Research Council
Note

Godkänd;2020;Nivå 0;2020-04-22 (cisjan)

Available from: 2020-03-05 Created: 2020-03-05 Last updated: 2020-04-22Bibliographically approved
Yu, J.-G., Isaksson, A., Rova, A., Tegner, Y., Eriksson, A. & Malm, C. (2020). Potential effects of long term abuse of anabolic androgen steroids on human skeletal muscle. Journal of Sports Medicine and Physical Fitness
Open this publication in new window or tab >>Potential effects of long term abuse of anabolic androgen steroids on human skeletal muscle
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2020 (English)In: Journal of Sports Medicine and Physical Fitness, ISSN 0022-4707, E-ISSN 1827-1928Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: We have previously evaluated muscle functions and morphology in power athletes of long term (5 to15 years) abuse of anabolic androgen steroids (AAS; Doped) and in clean power athletes (Clean), and observed significant improvements in both muscle morphology and muscle functions in Doped. To our knowledge, the effects of long term AAS abuse on human muscle protein profile have never been studied.

METHODS: The study examined further the muscle biopsies using a two-dimensional difference gel electrophoresis (2D DIGE) for proteomic screening and protein expression. Cellular localization/distribution of specific proteins identified by proteomic analysis was examined using immunohistochemistry (IHC).

RESULTS: Different protein profiles were observed between Doped and Clean, and a valid orthogonal projection of latent structure discriminant analysis model was built (N = 16, X = 5, R2 = 0.88/Q2 = 0.84, p = 0.0005), which separated Doped from Clean. Liquid chromatography followed by tandem spectrometry identified 14 protein spots (representing nine different proteins) of significant difference in relative quantity (p < 0.05), of which nine spots were down-regulated in Doped compared with Clean. IHC revealed no significant alteration in cellular localization in phosphoglucomutase-1 and heat shock protein beta-1, but indeed in two reference proteins desmin and F-actin in Doped.

CONCLUSIONS: Long term abuse of AAS in combination with training is potentially associated with alterations in skeletal muscle protein profile and protein expression, and structural proteins rather than non-structural proteins are preferentially affected in cellular localization/distribution.

Place, publisher, year, edition, pages
Edizioni Minerva Medica, 2020
Keywords
Long term doping, Anabolic androgen steroids, Skeletal muscle, Proteomic profiling, Protein expression
National Category
Nursing
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-78781 (URN)10.23736/S0022-4707.20.10443-2 (DOI)32343079 (PubMedID)
Available from: 2020-05-05 Created: 2020-05-05 Last updated: 2020-05-05
Adolfsson, L., Hallgren, H. B. & Tegner, Y. (2020). Union of Scaphoid Waist Fractures in Adults Despite No or Minimal Immobilization: a Report of Five Cases. SN Comprehensive Clinical Medicine
Open this publication in new window or tab >>Union of Scaphoid Waist Fractures in Adults Despite No or Minimal Immobilization: a Report of Five Cases
2020 (English)In: SN Comprehensive Clinical Medicine, E-ISSN 2523-8973Article in journal (Refereed) Epub ahead of print
Abstract [en]

Traditionally scaphoid waist fractures have been treated with a long period, 10–12 weeks, of immobilization in a plaster cast until radiological union. The long period of immobilization sometimes infers great discomfort for the patients. To avoid this, surgical treatment with screw fixation has for the last decade been advocated as an option also for undisplaced fractures. In this report, we present five cases with undisplaced scaphoid waist fractures that have healed both radiologically and clinically without any immobilization at all or after a very short period of protection in a cast. These observations challenge the current treatment guidelines.

Place, publisher, year, edition, pages
Springer, 2020
Keywords
Scaphoid fracture, Sports, Conservative treatment, Union
Identifiers
urn:nbn:se:ltu:diva-78249 (URN)10.1007/s42399-020-00257-5 (DOI)
Available from: 2020-03-31 Created: 2020-03-31 Last updated: 2020-03-31
Shahim, P., Tegner, Y., Chan, L., Zetterberg, H. & Blennow, K. (2019). Cerebrospinal fluid characterization of axonal injury, astroglial activation, and amyloid dysmetabolism of athletes with repetitive. Paper presented at The 37th Annual National Neurotrauma Symposium, June 29–July 3 2019, Pittsburgh, Pennsylvania. Journal of Neurotrauma, 36(13), A-24-A-25, Article ID A02-03.
Open this publication in new window or tab >>Cerebrospinal fluid characterization of axonal injury, astroglial activation, and amyloid dysmetabolism of athletes with repetitive
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2019 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 36, no 13, p. A-24-A-25, article id A02-03Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Mary Ann Liebert, 2019
Keywords
CSF, repetitive head trauma, tau, amyloid, astrogliosis
National Category
Medical and Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-78253 (URN)
Conference
The 37th Annual National Neurotrauma Symposium, June 29–July 3 2019, Pittsburgh, Pennsylvania
Note

Godkänd;2020;Nivå 0;2020-04-22 (cisjan)

Available from: 2020-03-31 Created: 2020-03-31 Last updated: 2020-04-22Bibliographically approved
Jonsson, J., Jonsson, M. & Tegner, Y. (2019). The Epidemiology of Overuse Injuries in Ice Hockey: An Analysis from 29 Seasons in the Swedish Elite League. Orthopedics and sports medicine, 2(4)
Open this publication in new window or tab >>The Epidemiology of Overuse Injuries in Ice Hockey: An Analysis from 29 Seasons in the Swedish Elite League
2019 (English)In: Orthopedics and sports medicine, ISSN 2638-6003, Vol. 2, no 4Article in journal (Refereed) Published
Abstract [en]

Background: An overuse injury is considered to be the result of iterated micro trauma or monotonous movements. Sports related to monotonous and repetitive movements have a high amount of overuse injuries. Ice hockey with its complexity of movements makes the player exposed to overuse injuries. The aim of this study was to analyze overuse injuries, and to study the long-term injury panorama. It is the first and essential step to obtain an injury-prevention method.Study Design: Descriptive epidemiological study.Method: Data from an elite ice hockey team was prospectively collected from 29 seasons. The definition of an overuse injury was a gradual onset injury caused by repeated micro trauma without a single identifiable event responsible for that injury and which resulted in absence from ice hockey. Result: 315 overuse injuries were registered and accounted for 16.2% of all injury registrations. An overuse injury led on average to 1.8 missed games, 6.5 missed training sessions and 8.4 days of absence. August and September were the most injury months for an injury, with a total of 38.7% of the events. The most affected body region was the hip and groin, as 67.3% of all overuse injuries arose there. The second and third most affected body regions were the back and the knee respectively.Conclusion: The present study reports that overuse injuries are a relevant problem. Primarily hip and groin are frequently affected. The beginning of the on-ice season has shown to be the most vulnerable period

Place, publisher, year, edition, pages
Lupine Publishers, 2019
Keywords
Overuse Injuries, Ice Hockey, Hip, Groin, Back, Knee
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-73531 (URN)10.32474/OSMOAJ.2019.02.000143 (DOI)
Available from: 2019-04-09 Created: 2019-04-09 Last updated: 2019-04-10Bibliographically approved
Arroyo-Morales, M., Martin-Alguacil, J., Lozano-Lozano, M., Cuesta-Vargas, A. I., Fernández-Fernández, A. J., González, J. A., . . . Cantarero-Villanueva, I. (2019). The Lysholm score: Cross cultural validation and evaluation of psychometric properties of the Spanish version. PLoS ONE, 14(8), Article ID e0221376.
Open this publication in new window or tab >>The Lysholm score: Cross cultural validation and evaluation of psychometric properties of the Spanish version
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2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 8, article id e0221376Article in journal (Refereed) Published
Abstract [en]

Background

This study aims at assessing the validity and reliability of the Spanish version of the Lysholm score, a widely used instrument for assessing knee function and activity level after ligament injuries.

Methods

Ninety-five participants (67.4% male, 22±5 years) completed the questionnaire twice within 7 days and a subsample of 42 participants completed a test-retest reliability. Reliability, validity and feasibility psychometric properties were studied. The validity of the questionnaire was analysed using ceiling and floor effects. Factor structure and construct validity were analysed with the SF-36, the Hip and Knee Questionnaire (HKQ) and one leg jump test (OLJT).

Results

Criterion validity with the SF-36 Physical State was moderate (r = 0.50 and p<0.01), poor and inverse relationship (r = -0.31, p<0.01) with HKQ and positive moderate (r = 0.59, p<0.01) with OLJT. Measurement error from MDC90 was 3.9%. Exploratory factor analysis demonstrated a one-factor solution explaining 51.5% of total variance. The x2 test for the one-factor model was significant (x2 = 29.58, df = 20, p < 0.08). Test-retest reliability level was high (ICC2.1 = 0.92, p<0.01) and also the internal consistency (α = 0.77).

Conclusion

The Spanish Lysholm score demonstrated that it is a reliable and valid instrument that can be used to assess knee function after ligament injuries.

Place, publisher, year, edition, pages
Public Library of Science, 2019
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-75857 (URN)10.1371/journal.pone.0221376 (DOI)000485049000018 ()31454386 (PubMedID)
Note

Validerad;2019;Nivå 2;2019-09-05 (johcin)

Available from: 2019-09-05 Created: 2019-09-05 Last updated: 2019-10-08Bibliographically approved
Vedung, F., Hanni, S., Tegner, Y., Johansson, J. & Marklund, N. (2018). CONCUSSION INCIDENCE IN SWEDISH ELITE SOCCER. Paper presented at 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, August 11-16, 2018, Toronto, CANADA. Journal of Neurotrauma, 35(16), A270-A270
Open this publication in new window or tab >>CONCUSSION INCIDENCE IN SWEDISH ELITE SOCCER
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2018 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 35, no 16, p. A270-A270Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
Mary Ann Liebert, 2018
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-71050 (URN)10.1089/neu.2018.29014.abstract.index (DOI)000441527400721 ()
Conference
3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, August 11-16, 2018, Toronto, CANADA
Note

Konferensartikel i tidskrift

Available from: 2018-10-01 Created: 2018-10-01 Last updated: 2018-10-01Bibliographically approved
Shahim, P., Tegner, Y., Blennow, K. & Zetterberg, H. (2018). Neurofilament Light and Tau in the Aftermath of Human Repetitive Concussive Traumatic Brain Injury. Paper presented at 70th Annual AAN Annual Meeting, April 21-27, 2018, Los Angeles, USA. Neurology, 80(15 Supplement), Article ID S49.002.
Open this publication in new window or tab >>Neurofilament Light and Tau in the Aftermath of Human Repetitive Concussive Traumatic Brain Injury
2018 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 80, no 15 Supplement, article id S49.002Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Wolters Kluwer, 2018
Identifiers
urn:nbn:se:ltu:diva-78255 (URN)000453090806018 ()
Conference
70th Annual AAN Annual Meeting, April 21-27, 2018, Los Angeles, USA
Available from: 2020-03-31 Created: 2020-03-31 Last updated: 2020-03-31
Shahim, P., Tegner, Y., Marklund, N., Höglund, K. & Portelius, E. (2017). Astroglial activation and altered amyloid metabolism in human repetitive concussion. Neurology, 88(15), 1400-1407
Open this publication in new window or tab >>Astroglial activation and altered amyloid metabolism in human repetitive concussion
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2017 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 88, no 15, p. 1400-1407Article in journal (Refereed) Published
Abstract [en]

Objective: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood–brain barrier (BBB) impairment.

Methods: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25–12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ). The main outcome measures were CSF concentrations of astroglial activation markers (glial fibrillary acidic protein [GFAP] and YKL-40), markers reflecting amyloid precursor protein metabolism (Aβ38, Aβ40, Aβ42, sAPPα, and sAPPβ), and BBB function (CSF:serum albumin ratio).

Results: Nine of the 28 athletes returned to play within a year, while 19 had persistent PCS >1 year. Athletes with PCS >1 year had higher RPQ scores and number of concussions than athletes with PCS <1 year. Median concentrations of GFAP and YKL-40 were higher in athletes with PCS >1 year compared with controls, although with an overlap between the groups. YKL-40 correlated with RPQ score and the lifetime number of concussions. Athletes with rcTBI had lower concentrations of Aβ40 and Aβ42 than controls. The CSF:serum albumin ratio was unaltered.

Conclusions: This study suggests that PCS may be associated with biomarker evidence of astroglial activation and β-amyloid (Aβ) dysmetabolism in the brain. There was no clear evidence of Aβ deposition as Aβ40 and Aβ42 were reduced in parallel. The CSF:serum albumin ratio was unaltered, suggesting that the BBB is largely intact in PCS.

Place, publisher, year, edition, pages
American Academy of Neurology, 2017
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-62510 (URN)10.1212/WNL.0000000000003816 (DOI)000398674100008 ()28283595 (PubMedID)2-s2.0-85018646525 (Scopus ID)
Note

Validerad; 2017; Nivå 2; 2017-04-12 (inah)

Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2018-11-20Bibliographically approved
Shahim, P., Tegner, Y., Broady, D. L., Blennow, K. & Zetterberg, H. (2017). Astroglial activation and altered amyloid metabolism in human repetitive concussive traumatic brain injury. Paper presented at Alzheimer's Association International Conference (AAIC) 2017, London, Jul 16 - 20, 2017. Alzheimer's & Dementia, 13(7 (Suppl)), P216-P217
Open this publication in new window or tab >>Astroglial activation and altered amyloid metabolism in human repetitive concussive traumatic brain injury
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2017 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 13, no 7 (Suppl), p. P216-P217Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2017
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-66252 (URN)10.1016/j.jalz.2017.07.093 (DOI)
Conference
Alzheimer's Association International Conference (AAIC) 2017, London, Jul 16 - 20, 2017
Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2017-11-24Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3628-0705

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