Change search
Link to record
Permanent link

Direct link
BETA
Publications (10 of 240) Show all publications
Vedung, F., Hanni, S., Tegner, Y., Johansson, J. & Marklund, N. (2018). CONCUSSION INCIDENCE IN SWEDISH ELITE SOCCER. Paper presented at 3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, August 11-16, 2018, Toronto, CANADA. Journal of Neurotrauma, 35(16), A270-A270
Open this publication in new window or tab >>CONCUSSION INCIDENCE IN SWEDISH ELITE SOCCER
Show others...
2018 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 35, no 16, p. A270-A270Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
Mary Ann Liebert, 2018
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-71050 (URN)10.1089/neu.2018.29014.abstract.index (DOI)000441527400721 ()
Conference
3rd Joint Symposium of the International-and-National-Neurotrauma-Societies-and-AANS/CNS-Section on Neurotrauma and Critical Care, August 11-16, 2018, Toronto, CANADA
Note

Konferensartikel i tidskrift

Available from: 2018-10-01 Created: 2018-10-01 Last updated: 2018-10-01Bibliographically approved
Shahim, P., Tegner, Y., Marklund, N., Höglund, K. & Portelius, E. (2017). Astroglial activation and altered amyloid metabolism in human repetitive concussion. Neurology, 88(15), 1400-1407
Open this publication in new window or tab >>Astroglial activation and altered amyloid metabolism in human repetitive concussion
Show others...
2017 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 88, no 15, p. 1400-1407Article in journal (Refereed) Published
Abstract [en]

Objective: To determine whether postconcussion syndrome (PCS) due to repetitive concussive traumatic brain injury (rcTBI) is associated with CSF biomarker evidence of astroglial activation, amyloid deposition, and blood–brain barrier (BBB) impairment.

Methods: A total of 47 participants (28 professional athletes with PCS and 19 controls) were assessed with lumbar puncture (median 1.5 years, range 0.25–12 years after last concussion), standard MRI of the brain, and Rivermead Post-Concussion Symptoms Questionnaire (RPQ). The main outcome measures were CSF concentrations of astroglial activation markers (glial fibrillary acidic protein [GFAP] and YKL-40), markers reflecting amyloid precursor protein metabolism (Aβ38, Aβ40, Aβ42, sAPPα, and sAPPβ), and BBB function (CSF:serum albumin ratio).

Results: Nine of the 28 athletes returned to play within a year, while 19 had persistent PCS >1 year. Athletes with PCS >1 year had higher RPQ scores and number of concussions than athletes with PCS <1 year. Median concentrations of GFAP and YKL-40 were higher in athletes with PCS >1 year compared with controls, although with an overlap between the groups. YKL-40 correlated with RPQ score and the lifetime number of concussions. Athletes with rcTBI had lower concentrations of Aβ40 and Aβ42 than controls. The CSF:serum albumin ratio was unaltered.

Conclusions: This study suggests that PCS may be associated with biomarker evidence of astroglial activation and β-amyloid (Aβ) dysmetabolism in the brain. There was no clear evidence of Aβ deposition as Aβ40 and Aβ42 were reduced in parallel. The CSF:serum albumin ratio was unaltered, suggesting that the BBB is largely intact in PCS.

National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-62510 (URN)10.1212/WNL.0000000000003816 (DOI)000398674100008 ()28283595 (PubMedID)2-s2.0-85018646525 (Scopus ID)
Note

Validerad; 2017; Nivå 2; 2017-04-12 (inah)

Available from: 2017-03-15 Created: 2017-03-15 Last updated: 2018-07-10Bibliographically approved
Shahim, P., Tegner, Y., Broady, D. L., Blennow, K. & Zetterberg, H. (2017). Astroglial activation and altered amyloid metabolism in human repetitive concussive traumatic brain injury. Paper presented at Alzheimer's Association International Conference (AAIC) 2017, London, Jul 16 - 20, 2017. Alzheimer's & Dementia, 13(7 (Suppl)), P216-P217
Open this publication in new window or tab >>Astroglial activation and altered amyloid metabolism in human repetitive concussive traumatic brain injury
Show others...
2017 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 13, no 7 (Suppl), p. P216-P217Article in journal, Meeting abstract (Refereed) Published
Place, publisher, year, edition, pages
Elsevier, 2017
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-66252 (URN)10.1016/j.jalz.2017.07.093 (DOI)
Conference
Alzheimer's Association International Conference (AAIC) 2017, London, Jul 16 - 20, 2017
Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2017-11-24Bibliographically approved
Pauelsen, M., Nyberg, G., Tegner, C. & Tegner, Y. (2017). Concussion in ice hockey: A Cohort Study Across 29 Seasons (ed.). Clinical Journal of Sports Medicine, 27(3), 283-287
Open this publication in new window or tab >>Concussion in ice hockey: A Cohort Study Across 29 Seasons
2017 (English)In: Clinical Journal of Sports Medicine, ISSN 1050-642X, E-ISSN 1536-3724, Vol. 27, no 3, p. 283-287Article in journal (Refereed) Published
Abstract [en]

Objective: The aim of this study was to analyse the concussion incidence rate ratios (IRR) across 29 seasons in a Swedish Hockey League team.Design: Cohort study over 29 seasons within one Swedish elite series ice hockey team. Participants: All players who were part of one Swedish elite ice hockey team during the research period gave consent for participation in the study.Independent Variables: Exposure to top level Swedish ice hockey. Main Outcome Measures: Incidence rate ratio for concussion as well as rehabilitation periods due to concussion were calculated and analysed.Results: During the research period, 267 players in total were part of the team. A total of 1638 traumatic injuries were registered of which 162 were concussions. Incidence rates ranged from 0/1,000 games during the first season to 118/1,000 games for the final recorded season. The incidence rate ratio was 1.06 (CI = 1.03-1.10) for the entire research period. A shift towards longer rehabilitation periods was discovered.Conclusions: This study showed a significant increase of concussion incidence rate and a trend towards longer rehabilitation periods due to concussion. Possible risk factors were discussed. Risk behaviour and rehabilitation protocols should be prioritized areas in the research of concussion in ice hockey. 

Keywords
Athletic Injuries, Brain Concussion, Incidence Rate, Ice Hockey, Medicine, Medicin
National Category
Physiotherapy Other Health Sciences
Research subject
Physiotherapy; Health Science
Identifiers
urn:nbn:se:ltu:diva-14641 (URN)10.1097/JSM.0000000000000347 (DOI)000400635100008 ()28449005 (PubMedID)2-s2.0-85019961240 (Scopus ID)e0dc05fc-0595-4ded-b6da-bd8d66a827b5 (Local ID)e0dc05fc-0595-4ded-b6da-bd8d66a827b5 (Archive number)e0dc05fc-0595-4ded-b6da-bd8d66a827b5 (OAI)
Note

Validerad; 2017; Nivå 2; 2017-05-02 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Leijon-Sundqvist, K., Tegner, Y., Olsson, F., Karp, K. & Lehto, N. (2017). Relation between dorsal and palmar hand skin temperatures during a cold stress test. Journal of Thermal Biology, 66, 87-92
Open this publication in new window or tab >>Relation between dorsal and palmar hand skin temperatures during a cold stress test
Show others...
2017 (English)In: Journal of Thermal Biology, ISSN 0306-4565, E-ISSN 1879-0992, Vol. 66, p. 87-92Article in journal (Refereed) Published
Abstract [en]

Hand skin temperature measurements have previously been performed on either dorsal or palmar sides and it is possible to find arguments for the advantage of both locations. Therefore, the aim of this study was to use dynamic infrared (IR) imaging to examine the relationship between dorsal and palmar hand skin temperature. The palmar and dorsal hand skin temperature before and after a cold stress test was measured with IR thermography in 112 healthy participants. Calculation of surface average temperature was made from nine regions of interest on each hand's dorsal and palmar side. Temperature values were recorded at baseline, directly after immersion of hands in vinyl gloves for one minute in water at 20 °C ± 0.5 °C (gloves removed), and after eight minutes rewarming. Results showed that: a) the skin temperatures on the dorsal and palmar sides of the hand are strongly correlated; b) the correlation is stronger on the fingers than on the carpometacarpal (CMC) area; c) the palmar side of the CMC area is warmer than the dorsal side, but this is reversed in the fingers so that the nail bed is warmer than the finger pad; and d) the temperature difference ∆T∆T between the dorsal and palmar sides of the fingers is independent of the skin temperature, though ∆T∆T on the CMC area of the hand is temperature dependent. Such differences can be important in detailed investigations of thermal phenomena in the hand. In conclusion, results showed a strong correlation between the dorsal and palmar temperatures. If both sides cannot be measured, the purpose of the investigation should determine which side of the hand should be measured.

Place, publisher, year, edition, pages
Elsevier, 2017
National Category
Other Health Sciences Other Medical Engineering
Research subject
Health Science; Medical Engineering for Healthcare
Identifiers
urn:nbn:se:ltu:diva-63050 (URN)10.1016/j.jtherbio.2017.04.003 (DOI)000401388300012 ()28477914 (PubMedID)2-s2.0-85017527831 (Scopus ID)
Note

Validerad; 2017; Nivå 2; 2017-04-28 (andbra)

Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2018-09-13Bibliographically approved
Shahim, P., Zetterberg, H., Tegner, Y. & Blennow, K. (2017). Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports. Neurology, 88(19), 1788-1794
Open this publication in new window or tab >>Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports
2017 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 88, no 19, p. 1788-1794Article in journal (Refereed) Published
Abstract [en]

Objective: To evaluate whether the axonal protein neurofilament light (NFL) in serum is a sensitive biomarker to detect subtle brain injury or concussion in contact sports athletes.

Methods: Two prospective cohort studies involving (1) 14 Swedish amateur boxers who underwent fluid biomarker assessments at 7–10 days after bout and after 3 months of rest from boxing and (2) 35 Swedish professional hockey players who underwent blood biomarker assessment at 1, 12, 36, and 144 hours after concussion and when the players returned to play were performed. Fourteen healthy nonathletic controls and 12 athletic controls were also enrolled. Serum NFL was measured using ultrasensitive single molecule array technology.

Results: Serum NFL concentrations were increased in boxers 7–10 days after bout as compared to the levels after 3 months rest as well as compared with controls (p = 0.0007 and p < 0.0001, respectively). NFL decreased following 3 months of rest, but was still higher than in controls (p < 0.0001). Boxers who received many (>15) hits to the head or were groggy after bout had higher concentrations of serum NFL as compared to those who received fewer hits to the head (p = 0.0023). Serum NFL increased over time in hockey players, and the levels returned to normal at return to play. Importantly, serum NFL could separate players with rapidly resolving postconcussion symptoms (PCS) from those with prolonged PCS.

Conclusions: The results from these 2 independent cohort studies suggest that serum NFL is a highly sensitive biomarker for concussion.

National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-63045 (URN)10.1212/WNL.0000000000003912 (DOI)000400752000007 ()28404801 (PubMedID)2-s2.0-85019837220 (Scopus ID)
Note

Validerad; 2017; Nivå 2; 2017-05-10 (rokbeg)

Available from: 2017-04-18 Created: 2017-04-18 Last updated: 2018-07-10Bibliographically approved
Shahim, P., Tegner, Y., Blennow, K. & Zetterberg, H. (2016). Cerebrospinal fluid biomarkers of neuronal injury in chronic traumatic brain injury. Paper presented at The Alzheimer's Association International Conference®, 2016 (AAIC®, Toronto, Canada, 24-28 July 2016. Alzheimer's & Dementia, 12(7 Suppl.), P1056
Open this publication in new window or tab >>Cerebrospinal fluid biomarkers of neuronal injury in chronic traumatic brain injury
2016 (English)In: Alzheimer's & Dementia, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 12, no 7 Suppl., p. P1056-Article in journal, Meeting abstract (Refereed) Published
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-59819 (URN)10.1016/j.jalz.2016.06.2205 (DOI)
Conference
The Alzheimer's Association International Conference®, 2016 (AAIC®, Toronto, Canada, 24-28 July 2016
Available from: 2016-10-19 Created: 2016-10-19 Last updated: 2017-11-29Bibliographically approved
Burman, E., Lysholm, J., Shahim, P., Malm, C. & Tegner, Y. (2016). Concussed athletes are more prone to injury both before and after their index concussion: data base analysis of 699 concussed contact sports athletes (ed.). BMJ Open Sport & Exercise Medicine, 2(1), Article ID e000092.
Open this publication in new window or tab >>Concussed athletes are more prone to injury both before and after their index concussion: data base analysis of 699 concussed contact sports athletes
Show others...
2016 (English)In: BMJ Open Sport & Exercise Medicine, ISSN 2055-7647, Vol. 2, no 1, article id e000092Article in journal (Refereed) Published
Abstract [en]

Background Ice hockey and football players suffering concussions might have an increased risk for injuries afterwards. We aimed to investigate if concussions predisposed athletes for subsequent sport injuries. Methods Patient data were obtained from a data base established at the University Hospital in Umea, Sweden. Athletes who had suffered a concussion were included if they had been aged between 15 and 35 years of age, and played ice hockey, football (soccer), floorball and handball. They were studied in terms of all new or previous injuries during 24 months before and after their concussion. Results were compared with a control group of athletes from the same four sports with an ankle injury. Results Athletes with a concussion were more likely to sustain injuries compared with the control group, both before (OR 1.98. 95% CI 1.45 to 2.72) and after the concussion (OR 1.72. 95% CI 1.26 to 2.37). No increase in frequency of injury was found after a concussion compared with before. This was true for athletes in all four sports and for both sexes. Conclusions This study indicates that athletes sustaining a concussion may have a more aggressive or risk-taking style of play than their counterparts. Our data do not suggest that a concussion injury, per se, leads to subsequent injuries.

National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-10738 (URN)10.1136/bmjsem-2015-000092 (DOI)27900166 (PubMedID)99526fe9-c97a-4f18-b137-7009affb1e7a (Local ID)99526fe9-c97a-4f18-b137-7009affb1e7a (Archive number)99526fe9-c97a-4f18-b137-7009affb1e7a (OAI)
Note

Godkänd; 2016; 20160401 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved
Eshuis, R., Lentjes, G. W., Tegner, Y., Wolterbeek, N. & Veen, M. R. (2016). Dutch Translation and Cross-cultural Adaption of the Lysholm Score and Tegner Activity Scale for Patients With Anterior Cruciate Ligament Injuries. Journal of Orthopaedic and Sports Physical Therapy, 46(11), 976-983
Open this publication in new window or tab >>Dutch Translation and Cross-cultural Adaption of the Lysholm Score and Tegner Activity Scale for Patients With Anterior Cruciate Ligament Injuries
Show others...
2016 (English)In: Journal of Orthopaedic and Sports Physical Therapy, ISSN 0190-6011, E-ISSN 1938-1344, Vol. 46, no 11, p. 976-983Article in journal (Refereed) Published
Abstract [en]

Study Design Clinical measurement. Background The Lysholm score and Tegner Activity Scale are frequently used patient-reported instruments to determine the functional status and activity level after anterior cruciate ligament (ACL) reconstruction. Objectives To translate and cross-culturally adapt the Lysholm score and Tegner Activity Scale for use in the Dutch population and to evaluate reliability and validity of these questionnaires in individuals after ACL reconstruction. Methods The translation and adaptation was conducted in several steps according to the guidelines in the literature. The measurement properties of the Lysholm score and Tegner Activity Scale (internal consistency, construct validity, and floor and ceiling effects) were tested in 96 patients. Reproducibility was tested in 69 patients, for patient with anterior cruciate ligament injuries. On the first occasion, the International Knee Documentation Committee (IKDC) and RAND-36 item Health Survey (RAND-36) were also administered. Results The Lysholm score and Tegner Activity Scale showed good test-retest reliability between repeated measures (respectively ICC 0.93 and 0.97). Internal consistency was reasonable to good (Cronbach's α=0.70-0.83). The Lysholm score had a very strong correlation with the IKDC (r= 0.83, p<0.01) and moderate correlation with the RAND-36 (r=0.55, p<0.01). The Tegner Activity Scale had a moderate correlation with both IKDC and the RAND-36 (r= 0.42 p<0.01 respectively r= 0.48 p<0.01). Conclusion This study demonstrated acceptable psychometric performances for the Lysholm score and the Tegner scale as outcome measures for Dutch patients after ACL reconstruction. J Orthop Sports Phys Ther, Epub 28 Sep 2016. doi:10.2519/jospt.2016.6566.

National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-36897 (URN)10.2519/jospt.2016.6566 (DOI)000387638800007 ()27681449 (PubMedID)2-s2.0-84994715827 (Scopus ID)
Note

Validerad; 2016; Nivå 2; 2016-11-15 (andbra)

Available from: 2016-10-03 Created: 2016-10-03 Last updated: 2018-07-10Bibliographically approved
Leijon-Sundqvist, K., Tegner, Y., Juntti, U., Karp, K. & Lehto, N. (2016). Hand skin temperature: are there warm and cold rewarming patterns after cold stress test? (ed.). Thermology International, 26(3), 81-87
Open this publication in new window or tab >>Hand skin temperature: are there warm and cold rewarming patterns after cold stress test?
Show others...
2016 (English)In: Thermology International, ISSN 1560-604X, Vol. 26, no 3, p. 81-87Article in journal (Refereed) Published
Abstract [en]

In 116 thermographic measurements of 66 healthy male participants, 44 of whom were measured at least twice, hand skin temperature distributions before and after a cold stress test (CST) were examined to identify any typical characteristics of hand skin rewarming. On each hand, measurements from 18 regions of interest recorded every 10 s were used to calculate the surface average temperature. Temperatures at baseline (Tb), directly after cooling (Tc), and after 15 min of rewarming (Tf) were used for comparison and the averages of each finger, palm, and hand were analyzed. Using fits of normal distribution for the measured data, final hand skin temperatures were divided into two groups, A and B, with a calculated boundary at 25.4 °C. Digital analyses of all thermograms were performed to describe the process, and each group's rewarming patterns were observed. Group A was considered to demonstrate warm rewarming, since the whole hands reached a Tf approximately equal to the Tb. By contrast, Group B demonstrated cold rewarming and had whole hand Tf less than Tb. The predictive value of Tc was lower than that of Tb in Group A, whereas the opposite occurred in Group B. Altogether, the findings suggest different hand skin temperature rewarming patterns in healthy males.

National Category
Other Health Sciences
Research subject
Health Science
Identifiers
urn:nbn:se:ltu:diva-11572 (URN)2-s2.0-85005987231 (Scopus ID)a94b21bd-cfa7-4507-ab07-0baf7a860395 (Local ID)a94b21bd-cfa7-4507-ab07-0baf7a860395 (Archive number)a94b21bd-cfa7-4507-ab07-0baf7a860395 (OAI)
Note

Validerad; 2016; Nivå 1; 2016-11-21 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-03-05Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3628-0705

Search in DiVA

Show all publications