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Haupt, Dan
Publications (10 of 38) Show all publications
Haupt, D. (2009). Aftertreatment strategy for reducing emissions from an ethanol fueled CI engine (ed.). In: (Ed.), SAE 2009 International Powertrains, Fuels & Lubricants Meeting: June 15 - 17, 2009, Grand Hotel Mediterraneo, Florence, Italy ; [papers]. Paper presented at SAE International Powertrains, Fuels & Lubricants Meeting : 15/06/2009 - 17/06/2009. Warrendale, Pa.: Society of Automotive Engineers, Incorporated
Open this publication in new window or tab >>Aftertreatment strategy for reducing emissions from an ethanol fueled CI engine
2009 (English)In: SAE 2009 International Powertrains, Fuels & Lubricants Meeting: June 15 - 17, 2009, Grand Hotel Mediterraneo, Florence, Italy ; [papers], Warrendale, Pa.: Society of Automotive Engineers, Incorporated , 2009Conference paper, Published paper (Refereed)
Abstract [en]

A nine liters ethanol-fueled CI engine was equipped with aftertreatment devices while different ratios of exhaust gas recirculation (EGR) were tested. The NO\dX emissions were negatively correlated to the EGR-ratio and NO\dX reductions of between 33% and 73% were obtained. Unfortunately, the decrease in NO\dX was followed by increased emissions of carbon monoxide, hydrocarbons, particulate matter and higher fuel consumption. The particle number emission increased approximately 4 times and particle sizes above 200 nm became more frequent when using EGR. The remedy for these emissions was to combine an oxidation catalyst and a diesel particle filter (DPF), while keeping the EGR-ratio low to minimize fuel consumption. Equipped like this, the engine passed the Euro 5 regulation as well as the Enhanced Environmentally Friendly Vehicles standard (EEV).

Place, publisher, year, edition, pages
Warrendale, Pa.: Society of Automotive Engineers, Incorporated, 2009
Series
S A E Technical Papers, ISSN 0148-7191
Identifiers
urn:nbn:se:ltu:diva-27106 (URN)10.4271/2009-01-1949 (DOI)07149b80-5c00-11de-9f57-000ea68e967b (Local ID)07149b80-5c00-11de-9f57-000ea68e967b (Archive number)07149b80-5c00-11de-9f57-000ea68e967b (OAI)
Conference
SAE International Powertrains, Fuels & Lubricants Meeting : 15/06/2009 - 17/06/2009
Note

Validerad; 2009; 20111201 (ysko)

Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2017-12-14Bibliographically approved
Haupt, D. & Nilsson, J. L. (2009). Asthma medication: persistence with adrenergics, steroids and combination products over a 5-year period (ed.). Journal of clinical pharmacology, 34(5), 507-513
Open this publication in new window or tab >>Asthma medication: persistence with adrenergics, steroids and combination products over a 5-year period
2009 (English)In: Journal of clinical pharmacology, ISSN 0091-2700, E-ISSN 1552-4604, Vol. 34, no 5, p. 507-513Article in journal (Refereed) Published
Abstract [en]

Background: Many patients with asthma underuse steroids for inhalation. This has been identified as a main cause of therapy failure and of excess health care utilization.Objective: To elucidate the medication persistence of patients using asthma drugs, how patients combine the drugs over time and whether medication persistence was influenced by patients switching to combination products.Methods: Individual patients' drug acquisition data were obtained from a pharmacy record database for the period 2000-2004. A patient was considered to have satisfactory medication possession ratio (MPR) if the medication supplies covered ≥80% of the prescribed treatment. Drug use profiles were constructed as graphs for each patient, showing the date of each refill and the time period covered by the dispensed drugs. From the graphs the combination of drugs, the continuity of the therapy over time and the MPR for each patient could be determined.Results: Of 1812 patients with asthma drugs in the database, 815 fulfilled the inclusion criteria. The percentage of patients with satisfactory MPR was low (11-27%), but significantly higher among patients using combination products than among those using steroids. For patients who switched from adrenergics plus steroids in two inhalers to combination products in one inhaler, the number of patients with satisfactory MPR was significantly increased.Conclusion: Satisfactory MPR was low for all types of asthma drugs. More patients had satisfactory MPR with combination products in one inhaler than with adrenergics and steroids in two separate inhalers. Asthma drug-delivery is important and combination products of the two ingredients could therefore improve asthma therapy.

Identifiers
urn:nbn:se:ltu:diva-15796 (URN)10.1111/j.1365-2710.2009.01026.x (DOI)000269591600002 ()2-s2.0-70049118666 (Scopus ID)f59ba1f0-ec4c-11dd-99cd-000ea68e967b (Local ID)f59ba1f0-ec4c-11dd-99cd-000ea68e967b (Archive number)f59ba1f0-ec4c-11dd-99cd-000ea68e967b (OAI)
Note

Validerad; 2009; 20090127 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Nilsson, J. L., Haupt, D., Krigsman, L. & Moen, J. (2009). Asthma/COPD drugs reflecting disease prevalence, patient adherence and persistence (ed.). Expert Review of Respiratory Medicine, 3(1), 93-101
Open this publication in new window or tab >>Asthma/COPD drugs reflecting disease prevalence, patient adherence and persistence
2009 (English)In: Expert Review of Respiratory Medicine, ISSN 1747-6348, Vol. 3, no 1, p. 93-101Article in journal (Refereed) Published
Abstract [en]

The aim of this review is to discuss the methodological issues involved in using pharmacy-record databases of drug sales in pharmacoepidemiology and to illustrate the usefulness of such data in estimating disease prevalence, patient adherence and persistence to therapy. Recent studies show that asthma/chronic obstructive pulmonary disease (COPD) prevalence increases with age. The volume of acquired asthma/COPD drugs per patient also increases with age and was approximately 2.5-times higher for patients aged 60-69 years compared with patients aged 20-29 years. Despite this, there is a comparatively low interest in asthma/COPD research involving elderly individuals. Published asthma/COPD-prevalence data and drug-treatment-prevalence data correspond reasonably well. Short- as well as long-term studies on drug acquisition indicate that approximately a third of patients have drugs available to cover at least 80% of the prescribed treatment time. Only approximately a tenth of the patients acquired steroids or steroid combinations, corresponding to one daily defined dose per day over a 5-year treatment period. It is probable that asthma/COPD is undertreated in all age groups.

Identifiers
urn:nbn:se:ltu:diva-4665 (URN)10.1586/17476348.3.1.93 (DOI)2-s2.0-70049107919 (Scopus ID)2a4e39b0-ec63-11dd-99cd-000ea68e967b (Local ID)2a4e39b0-ec63-11dd-99cd-000ea68e967b (Archive number)2a4e39b0-ec63-11dd-99cd-000ea68e967b (OAI)
Note

Godkänd; 2009; 20090127 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Haupt, D., Weitoft, G. R. & Nilsson, J. L. (2009). Refill adherence to oral antihyperglycaemic drugs in Sweden (ed.). Acta Diabetologica, 46(3), 203-208
Open this publication in new window or tab >>Refill adherence to oral antihyperglycaemic drugs in Sweden
2009 (English)In: Acta Diabetologica, ISSN 0940-5429, E-ISSN 1432-5233, Vol. 46, no 3, p. 203-208Article in journal (Refereed) Published
Abstract [en]

Only 49% of the patients with T2D in Sweden that medicate with oral antihyperglycaemic drugs (AHGD) had good blood glucose control (HbA1C < 6.0%). The reason can be low medication adherence. The aim of this study was, therefore, to determine the adherence to different oral AHGD. Included were all patients in Sweden, older than 40 years and having at least two expenditures of AHGD between 1 December 2005 and 30 November 2006. After exclusions of inpatients and patients with unspecified daily dosage 171,220 patients (57% men) remained. Medication possession ratio (MPR) was used for estimating adherence and patients were regarded adherent if MPR ≥80%. The overall refill adherence average 90%, with mean MPR (SD) = 107% (30). Eighty-five percent of the patients in their 40s were adherent compared to 91% of the patients in their 80s. About 90.1% of the women were adherent whereas 89.5% of the men were adherent. Patients with an indication for the medicine were more adherent than patients without this information. We conclude that the unsatisfactory blood glucose control showed among many Swedish T2D patients is not the result of non-adherence to prescribed medication.

Identifiers
urn:nbn:se:ltu:diva-12402 (URN)10.1007/s00592-008-0076-1 (DOI)000268291900006 ()19023514 (PubMedID)2-s2.0-69849090238 (Scopus ID)b8adeac0-ec4f-11dd-99cd-000ea68e967b (Local ID)b8adeac0-ec4f-11dd-99cd-000ea68e967b (Archive number)b8adeac0-ec4f-11dd-99cd-000ea68e967b (OAI)
Note

Validerad; 2009; 20090127 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Haupt, D., Wettermark, B. & Nilsson, J. L. (2008). Dispensed volumes of anti-asthmatic drugs related to the prevalence of asthma and COPD in Sweden (ed.). Pharmacoepidemiology and Drug Safety, 17(5), 461-7
Open this publication in new window or tab >>Dispensed volumes of anti-asthmatic drugs related to the prevalence of asthma and COPD in Sweden
2008 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 17, no 5, p. 461-7Article in journal (Refereed) Published
Abstract [en]

To explore the possibility of using dispensed volumes asthma/COPD drugs as a proxy for the combined prevalence of asthma plus COPD. METHODS: The proportions of the Swedish population with inhalation drugs for asthma/COPD 2004 were obtained using three different databases. A pharmacy record database gave the volumes of dispensed drugs (defined daily doses, DDDs of R03A + R03B drugs) for each patient, 20 years and older. The X-plain database of Apoteket AB gave drug sales data for Sweden and Swedish population data were obtained from Swedish statistics. RESULTS: The sales volumes of asthma/COPD drugs were much higher for older than for younger people. The volumes increased from 18 DDD/TID for the 20-29 year group up to 124 DDD/TID for patients 70-79 years, or about seven times. The average volumes per patient in the different age groups corresponded to one DDD/day in only three of the age groups (50-79 years). In the youngest group the average drug volume per patient corresponded to one DDD every second day, which may indicate undermedication. The percentages of the Swedish population with asthma/COPD drugs increased from 4.0% for 20-29 years old to 14.5% for 80+ years old, or 3.6 times. When head-to-head comparisons could be made between reported prevalence data of asthma and COPD and our data the two sets of data were in a reasonable agreement. CONCLUSION: The prevalence of drug treatment, i.e. the proportion of the population with dispensed asthma/COPD drugs, could function as a proxy for the disease prevalence of asthma plus COPD.

Identifiers
urn:nbn:se:ltu:diva-7217 (URN)10.1002/pds.1564 (DOI)000256124500005 ()18302301 (PubMedID)2-s2.0-44249090927 (Scopus ID)58beeed0-3baa-11dd-8e42-000ea68e967b (Local ID)58beeed0-3baa-11dd-8e42-000ea68e967b (Archive number)58beeed0-3baa-11dd-8e42-000ea68e967b (OAI)
Note

Validerad; 2008; 20080616 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Haupt, D. & Nord, K. (2008). Emissioner och emissionsfaktorer från fyra arbetsmaskiner: mätning av reglerade och ickereglerade emissioner (ed.). Paper presented at . Luleå: Luleå tekniska universitet
Open this publication in new window or tab >>Emissioner och emissionsfaktorer från fyra arbetsmaskiner: mätning av reglerade och ickereglerade emissioner
2008 (Swedish)Report (Other academic)
Abstract [sv]

Arbetsmaskiner förbrukar en mycket stor del av det dieselbränsle som används i landet. En stor del av avgasemissionerna härrör följaktligen från dessa maskiner. Det är därför viktigt att ta fram kunskap om vilka emissioner som avges och på vilka olika sätt emissionerna kan minskas. Som ett led i detta arbete har projektet "Utveckling av relevanta arbetscykler och emissionsfaktorer samt reducering av bränsleförbrukningen för arbetsmaskiner" (EMMA) genomförts. Projektet har finansierats av Kommunikationsforskningsberedningen (numera en del av VINNOVA), Energimyndigheten, Vägverket och LRF. Dessutom har Volvo Wheel Loaders ställt motorer och Valtra Traktor AB traktorer och motorer tillprojektets förfogande. Vidare har JTI disponerat en större traktor från Lantmännens Maskin Import AB.Projektet har genomförts av ett konsortium bestående av:Luleå tekniska universitet (LTU)JTI - Institutet för jordbruks- och miljöteknik (JTI)Institutionen för lantbruksteknik SLU (LT)SkogForsk (Skog)Svensk Maskinprovning AB (SMP)Vägverket Produktion (VägvP)I denna rapport sammanfattar Luleå Tekniska Universitet sina resultat från emissionsmätningarna i EMMA projektet. Mätningarna omfattar fyra arbetsmaskiner som har körts i motorprovbänk enligt en 22- punkters testcykel. Motorerna som testades var en Sisu Diesel 620 DWRE, en Volvo TD63 KDE, en Volvo TD40 GJE samt en Sisu diesel 420 DWRE. Motorerna testades vid Luleå Tekniska Universitets motorlaboratorium samt vid Svensk maskinprovning i Umeå. Både reglerade och icke-reglerade emissioner har uppmätts. De reglerade emissionerna som har mätts är HC, NOX och CO. De icke reglerade komponenterna som analyserats är formaldehyd, acetaldehyd, akrolein, bensaldehyd, etan, eten, propan, propen, propyn, isobutan, acetylen, 1-buten, isobuten, pentan, 1,3-butadien, bensen, toluen, M-xylen och O-xylen.Genom att använda uppmätta tidsprocentvärden från ett antal olika arbetsoperationer, som därefter har fördelats enligt moderna i ISO 8178, har emissionsfaktorer för ett antal olika arbetsoperationer genererats.

Place, publisher, year, edition, pages
Luleå: Luleå tekniska universitet, 2008. p. 32
Series
Technical report / Luleå University of Technology, ISSN 1402-1536 ; 2008:26
Identifiers
urn:nbn:se:ltu:diva-24327 (URN)a8124fd0-eba0-11dd-99cd-000ea68e967b (Local ID)a8124fd0-eba0-11dd-99cd-000ea68e967b (Archive number)a8124fd0-eba0-11dd-99cd-000ea68e967b (OAI)
Note

Godkänd; 2008; 20090126 (ysko)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-12-14Bibliographically approved
Haupt, D., Krigsman, K. & Nilsson, J. L. (2008). Medication persistence among patients with asthma/COPD drugs (ed.). Pharmacy World & Science, 30(5), 509-514
Open this publication in new window or tab >>Medication persistence among patients with asthma/COPD drugs
2008 (English)In: Pharmacy World & Science, ISSN 0928-1231, E-ISSN 1573-739X, Vol. 30, no 5, p. 509-514Article in journal (Refereed) Published
Abstract [en]

Objective To determine medication possession ratio (MPR) of patients with asthma/COPD drugs. Method Individual patient's volumes of asthma/COPD drugs (ATC-code R03) for 2000-2004 were obtained from a pharmacy record database. For each patient the MPR was calculated as the percentage of the treatment time that the patient had drugs available. Main outcome measure Medication possession ratio (MPR). Results A total of 1,812 patients, 20 years and older, with dispensed asthma/COPD drugs were registered in the database, 928 patients (51%) had acquired drugs less than once per year (68% for 20-29 years old) during the 5-year study. Only 13% of the patients had steroids and steroid combinations available to allow continuous treatment. Eight percent of the patients 20-29 years old had MPR >/= 80% of all the included drugs and 5% when only steroids and steroid combinations were considered. About 25% of the patients had acquired 80% of the total volume of asthma/COPD drugs. Conclusion The majority of the patients, and particularly those in the youngest age group used asthma/COPD drugs only sporadically. This may indicate undermedication which is likely to have a negative impact on patient outcome.

Identifiers
urn:nbn:se:ltu:diva-15785 (URN)10.1007/s11096-008-9197-4 (DOI)000259443000004 ()18247154 (PubMedID)2-s2.0-52549099168 (Scopus ID)f5509140-3baa-11dd-8e42-000ea68e967b (Local ID)f5509140-3baa-11dd-8e42-000ea68e967b (Archive number)f5509140-3baa-11dd-8e42-000ea68e967b (OAI)
Note

Validerad; 2008; 20080616 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Nord, K. & Haupt, D. (2008). Statistical evaluation of rapeseed methyl ester as ignition improver in an 11 liters ethanol fuelled diesel engine (ed.). Paper presented at . Luleå: Luleå tekniska universitet
Open this publication in new window or tab >>Statistical evaluation of rapeseed methyl ester as ignition improver in an 11 liters ethanol fuelled diesel engine
2008 (English)Report (Other academic)
Abstract [en]

There is an ongoing search for better and cheaper ignition improvers to facilitate the introduction of ethanol fuel. Rapeseed methyl ester (RME) was therefore investigated in an ethanol fueled compression-ignited engine by means of different statistical designs. Experiments were accordingly performed at various levels of speed, load and concentration of RME in ethanol while the emissions were measured. The optimization criterions were; satisfactory engine performance and low exhaust emissions. Initial experiments showed that the power outlet and the opacity increased when using the tested ignition improver. A three level full factorial design correctly predicted that the emissions of HC, CO and NOX, should increase when using RME as an ignition improver. Lowest level of exhaust emissions was obtained at 16 % RME in ethanol but a higher concentration should be used to obtain better engine performance. A general conclusion is that RME seems suitable for the investigated task, i.e. ignition improvement, but the opacity increment should be further studied. Careful selection of the conditions used as well as rigorous control of the engine and dynamometer is necessary to obtain good repeatability and accuracy of the experimental conditions.

Place, publisher, year, edition, pages
Luleå: Luleå tekniska universitet, 2008. p. 7
Series
Technical report / Luleå University of Technology, ISSN 1402-1536 ; 2008:27
Identifiers
urn:nbn:se:ltu:diva-23421 (URN)6e481530-eba2-11dd-99cd-000ea68e967b (Local ID)6e481530-eba2-11dd-99cd-000ea68e967b (Archive number)6e481530-eba2-11dd-99cd-000ea68e967b (OAI)
Note

Godkänd; 2008; 20090126 (ysko)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-12-15Bibliographically approved
Weitoft, G. R., Haupt, D. & Nilsson, L. G. (2007). Adherence to oral type 2 diabetes mellitus drugs in Sweden (ed.). In: (Ed.), Nordic meeting in Epidemiology and Register-based Health Research: June 18-19, 2007 in Gothenburg, Sweden. Paper presented at Nordic meeting in Epidemiology and Register-based Health Research : 18/06/2007 - 19/06/2007.
Open this publication in new window or tab >>Adherence to oral type 2 diabetes mellitus drugs in Sweden
2007 (English)In: Nordic meeting in Epidemiology and Register-based Health Research: June 18-19, 2007 in Gothenburg, Sweden, 2007Conference paper, Published paper (Other academic)
Identifiers
urn:nbn:se:ltu:diva-39684 (URN)e871a350-6cee-11dc-89fb-000ea68e967b (Local ID)e871a350-6cee-11dc-89fb-000ea68e967b (Archive number)e871a350-6cee-11dc-89fb-000ea68e967b (OAI)
Conference
Nordic meeting in Epidemiology and Register-based Health Research : 18/06/2007 - 19/06/2007
Note

Godkänd; 2007; 20070927 (andbra)

Available from: 2016-10-03 Created: 2016-10-03 Last updated: 2017-12-15Bibliographically approved
Berg, C., Haupt, D. & Ekedahl, A. (2007). Prescriptions on split tablets: a common drug related problem - but unnecessary? (ed.). In: (Ed.), Tackling inequalities in the delivery of of pharmaceutical care: 7th ESCP Spring conference on clinical pharmacy : Edinburgh, 16-19 May 2007. Paper presented at ESCP spring conference on clinical pharmacy : Tackling inequalities in the delivery of pharmaceutical care 16/05/2007 - 19/05/2007 (pp. 16). ESCP
Open this publication in new window or tab >>Prescriptions on split tablets: a common drug related problem - but unnecessary?
2007 (English)In: Tackling inequalities in the delivery of of pharmaceutical care: 7th ESCP Spring conference on clinical pharmacy : Edinburgh, 16-19 May 2007, ESCP , 2007, p. 16-Conference paper, Published paper (Refereed)
Place, publisher, year, edition, pages
ESCP, 2007
Identifiers
urn:nbn:se:ltu:diva-34005 (URN)817dcad0-ed34-11dd-8bf2-000ea68e967b (Local ID)817dcad0-ed34-11dd-8bf2-000ea68e967b (Archive number)817dcad0-ed34-11dd-8bf2-000ea68e967b (OAI)
Conference
ESCP spring conference on clinical pharmacy : Tackling inequalities in the delivery of pharmaceutical care 16/05/2007 - 19/05/2007
Note

Godkänd; 2007; 20090128 (andbra)

Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2017-12-15Bibliographically approved
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