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Munavirov, Bulat
Publications (2 of 2) Show all publications
Filippov, A., Munavirov, B., Gröbner, G. & Rudakova, M. (2012). Lateral diffusion in equimolar mixtures of natural sphingomyelins with dioleoylphosphatidylcholine (ed.). Paper presented at . Magnetic Resonance Imaging, 30(3), 412-421
Open this publication in new window or tab >>Lateral diffusion in equimolar mixtures of natural sphingomyelins with dioleoylphosphatidylcholine
2012 (English)In: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 30, no 3, p. 412-421Article in journal (Refereed) Published
Abstract [en]

Cellular membranes of mammals are composed of a complex assembly of diverse phospholipids. Sphingomyelin (SM) and phosphatidylcholine (PC) are important lipids of eukaryotic cellular membranes and neuronal tissues, and presumably participate in the formation of membrane domains, known as “rafts,” through intermolecular interaction and lateral microphase decomposition. In these two-dimensional membrane systems, lateral diffusion of lipids is an essential dynamic factor, which might even be indicative of lipid phase separation process. Here, we used pulsed field gradient nuclear magnetic resonance to study lateral diffusion of lipid components in macroscopically oriented bilayers composed of equimolar mixtures of natural SMs of egg yolk, bovine brain, bovine milk and dipalmitoylphosphatidylcholine (DPPC) with dioleoylphosphatidylcholine (DOPC). In addition, differential scanning calorimetry was used as a complementary technique to characterize the phase state of the lipid bilayers. In fully liquid bilayers, the lateral diffusion coefficients in both DOPC/DPPC and DOPC/SM systems exhibit mean values of the pure bilayers. For DOPC/SM bilayer system, this behavior can be explained by a model where most SM molecules form short-lived lateral domains with preferential SM–SM interactions occurring within them. However, for bilayers in the presence of their low-temperature gel phase, lateral diffusion becomes complicated and cannot simply be understood solely by a simple change in the liquid phase decomposition.

National Category
Physical Chemistry
Research subject
Chemistry of Interfaces
Identifiers
urn:nbn:se:ltu:diva-9089 (URN)10.1016/j.mri.2011.12.010 (DOI)000300966500013 ()2-s2.0-84857107902 (Scopus ID)7a6b42b4-8306-41ed-8c37-d6f1ba793367 (Local ID)7a6b42b4-8306-41ed-8c37-d6f1ba793367 (Archive number)7a6b42b4-8306-41ed-8c37-d6f1ba793367 (OAI)
Note
Validerad; 2012; 20120120 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
Filippov, A., Munavirov, B. & Antzutkin, O. (2012). Phase transition, ordering and lateral diffusion in phospholipid bilayers in the presence of poly(ethylene oxide) (ed.). Paper presented at . Mendeleev communications (Print), 22(5), 250-251
Open this publication in new window or tab >>Phase transition, ordering and lateral diffusion in phospholipid bilayers in the presence of poly(ethylene oxide)
2012 (English)In: Mendeleev communications (Print), ISSN 0959-9436, E-ISSN 1364-551X, Vol. 22, no 5, p. 250-251Article in journal (Refereed) Published
Abstract [en]

The thermal behaviour, molecular orientation and lateral diffusion in the bilayered systems of dimyristoylphosphatidylcholine (DMPC) in the presence of poly(ethylene oxide) (PEO) were studied by NMR and DSC techniques, and it was found that PEO decreases the melting temperature (of vesicles and flat multibilayers) and affects the degree of orientation of DMPC molecules relative to the bilayer normal, but it does not influence the lateral diffusion of DMPC molecules

National Category
Physical Chemistry
Research subject
Chemistry of Interfaces
Identifiers
urn:nbn:se:ltu:diva-15890 (URN)10.1016/j.mencom.2012.09.007 (DOI)000310823600007 ()2-s2.0-84867539006 (Scopus ID)f74dfde2-a204-4807-9b17-e7047da7c75a (Local ID)f74dfde2-a204-4807-9b17-e7047da7c75a (Archive number)f74dfde2-a204-4807-9b17-e7047da7c75a (OAI)
Note
Validerad; 2012; 20121016 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved
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