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Bashir, M., Basna, R., Hedman, L., Backman, H., Ekerljung, L., Wennergren, G., . . . Nwaru, B. I. (2023). Interactive effect of socioeconomic status and smoking on the risk of allergic and nonallergic asthma among certain occupation groups – Results from two Swedish large adult populations: A Nordic Epilung study. In: Special Issue: Abstracts from the European Academy of Allergy and Clinical Immunology Hybrid Congress, 1‐3 July 2022: . Paper presented at European Academy of Allergy and Clinical Immunology, EAACI Hybrid Congress/Prague, Czech Republic, July 1‐3, 2022 (pp. 220-220). John Wiley & Sons, 78, Article ID 001190.
Open this publication in new window or tab >>Interactive effect of socioeconomic status and smoking on the risk of allergic and nonallergic asthma among certain occupation groups – Results from two Swedish large adult populations: A Nordic Epilung study
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2023 (English)In: Special Issue: Abstracts from the European Academy of Allergy and Clinical Immunology Hybrid Congress, 1‐3 July 2022, John Wiley & Sons, 2023, Vol. 78, p. 220-220, article id 001190Conference paper, Oral presentation with published abstract (Other academic)
Place, publisher, year, edition, pages
John Wiley & Sons, 2023
Series
Allergy, E-ISSN 1398-9995 ; S111
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-97587 (URN)10.1111/all.15616 (DOI)
Conference
European Academy of Allergy and Clinical Immunology, EAACI Hybrid Congress/Prague, Czech Republic, July 1‐3, 2022
Available from: 2023-05-24 Created: 2023-05-24 Last updated: 2023-05-24Bibliographically approved
Schyllert, C., Lindberg, A., Hedman, L., Stridsman, C., Andersson, M., Andersén, H., . . . Backman, H. (2023). Socioeconomic inequalities in asthma and respiratory symptoms in a high-income country: changes from 1996 to 2016. Journal of Asthma, 60(1), 185-194
Open this publication in new window or tab >>Socioeconomic inequalities in asthma and respiratory symptoms in a high-income country: changes from 1996 to 2016
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2023 (English)In: Journal of Asthma, ISSN 0277-0903, E-ISSN 1532-4303, Vol. 60, no 1, p. 185-194Article in journal (Refereed) Published
Abstract [en]

Objective: Low socioeconomic status based both on educational level and income has been associated with asthma and respiratory symptoms, but changes over time in these associations have rarely been studied. The aim was to study the associations between educational or income inequality and asthma and respiratory symptoms among women and men over a 20-year period in northern Sweden. Methods: The study was performed within the Obstructive Lung disease in Northern Sweden (OLIN) research program. Mailed questionnaire surveys were administered to a random sample of adults (20-69 years of age) living in Sweden, in 1996, 2006 and 2016. Data on educational level and income were collected from the national integrated database for labor market research. Results: The educational inequality associated with asthma and asthmatic wheeze tended to decrease from 1996 to 2016, while it increased for productive cough, the latter among men not among women. The income inequality decreased for productive cough, especially for women, while no clear overall trends were found for asthmatic wheeze and asthma, apart from a decrease in income inequality regarding asthma among men. Conclusion: The patterns for socioeconomic inequality differed for asthma and wheeze compared to productive cough, and the results emphasize that education and income do not mirror the same aspects of socioeconomic inequality in a high-income country. Our findings are important for decision makers, not the least on a political level, as reduced inequality, e.g. through education, could lead to reduced morbidity.

Place, publisher, year, edition, pages
Taylor & Francis, 2023
Keywords
Asthma, Respiratory symptoms, Socioeconomic status, Socioeconomic inequality, Epidemiology
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-89382 (URN)10.1080/02770903.2022.2039937 (DOI)000757219500001 ()35167415 (PubMedID)2-s2.0-85125363838 (Scopus ID)
Funder
NordForskSwedish Heart Lung FoundationSwedish Asthma and Allergy AssociationVisare Norr
Note

Validerad;2023;Nivå 2;2023-03-15 (joosat);

Funder: Umeå University and Västerbotten County Council (Avtal om läkarutbildning och forskning, ALF); Norrbotten County Council

Available from: 2022-02-23 Created: 2022-02-23 Last updated: 2023-03-15Bibliographically approved
Bashir, M. B., Basna, R., Zhang, G.-Q., Backman, H., Lindberg, A., Ekerljung, L., . . . Nwaru, B. I. (2022). Computational phenotyping of obstructive airway diseases: protocol for a systematic review. Systematic Reviews, 11(1), Article ID 216.
Open this publication in new window or tab >>Computational phenotyping of obstructive airway diseases: protocol for a systematic review
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2022 (English)In: Systematic Reviews, E-ISSN 2046-4053, Vol. 11, no 1, article id 216Article, review/survey (Refereed) Published
Abstract [en]

Background: Over the last decade, computational sciences have contributed immensely to characterization of phenotypes of airway diseases, but it is difficult to compare derived phenotypes across studies, perhaps as a result of the different decisions that fed into these phenotyping exercises. We aim to perform a systematic review of studies using computational approaches to phenotype obstructive airway diseases in children and adults.

Methods and analysis: We will search PubMed, Embase, Scopus, Web of Science, and Google Scholar for papers published between 2010 and 2020. Conferences proceedings, reference list of included papers, and experts will form additional sources of literature. We will include observational epidemiological studies that used a computational approach to derive phenotypes of chronic airway diseases, whether in a general population or in a clinical setting. Two reviewers will independently screen the retrieved studies for eligibility, extract relevant data, and perform quality appraisal of included studies. A third reviewer will arbitrate any disagreements in these processes. Quality appraisal of the studies will be undertaken using the Effective Public Health Practice Project quality assessment tool. We will use summary tables to describe the included studies. We will narratively synthesize the generated evidence, providing critical assessment of the populations, variables, and computational approaches used in deriving the phenotypes across studies

Conclusion: As progress continues to be made in the area of computational phenotyping of chronic obstructive airway diseases, this systematic review, the first on this topic, will provide the state of the art on the field and highlight important perspectives for future works.

Ethics and dissemination: No ethical approval is needed for this work is based only on the published literature and does not involve collection of any primary or human data.

Place, publisher, year, edition, pages
Springer Nature, 2022
Keywords
Airway disease, Asthma, Clustering, Computation, COPD, Machine learning, Phenotype, Systematic review
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-93738 (URN)10.1186/s13643-022-02078-0 (DOI)000867673700003 ()36229872 (PubMedID)2-s2.0-85139812629 (Scopus ID)
Funder
Swedish Research CouncilSwedish Asthma and Allergy AssociationRegion Västra GötalandRegion VästerbottenSwedish Heart Lung FoundationKnut and Alice Wallenberg FoundationUmeå UniversityUniversity of GothenburgNorrbotten County Council
Note

Validerad;2022;Nivå 2;2022-11-07 (hanlid);

Funder: Herman Krefting Foundation for Asthma and Allergy Research; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg

Available from: 2022-11-07 Created: 2022-11-07 Last updated: 2022-11-17Bibliographically approved
Bermúdez Barón, N., Lindberg, A., Stridsman, C., Andersson, M., Hedman, L., Vikjord, S. A., . . . Backman, H. (2021). Among respiratory symptoms, wheeze associates most strongly with impaired lung function in adults with asthma: a long-term prospective cohort study. BMJ Open Respiratory Research, 8(1), Article ID e000981.
Open this publication in new window or tab >>Among respiratory symptoms, wheeze associates most strongly with impaired lung function in adults with asthma: a long-term prospective cohort study
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2021 (English)In: BMJ Open Respiratory Research, E-ISSN 2052-4439, Vol. 8, no 1, article id e000981Article in journal (Refereed) Published
Abstract [en]

Background Asthma is a common disease and a major public health concern. Respiratory symptoms are related to its prognosis, which in turn associates with lung function. Still this association on a long-term basis is not entirely understood.

Aim To study the association of the type and number of respiratory symptoms with FEV1 and FEV1 decline in women and men with asthma.

Method A population-based cohort of adults with asthma was examined at study entry between 1986 and 2001 and at follow-up between 2012 and 2014, and n=977 had valid measurements of FEV1 on both occasions. Data regarding respiratory symptoms at study entry (recurrent wheeze, dyspnoea, longstanding cough and productive cough) were analysed in relation to FEV1 and annual decline in FEV1, both unadjusted and adjusted for other potentially associated factors by linear regression.

Results For both sexes recurrent wheeze and dyspnoea were associated with lower FEV1 at study entry and follow-up, while productive cough was associated with lower FEV1 only at follow-up. No associations were found between the type of symptoms and annual decline in FEV1. In adjusted analyses, the association between recurrent wheeze and lower FEV1 both at study entry and follow-up remained significant among women. Also, the association between a higher number of symptoms with lower FEV1 both at study entry and follow-up were present for both sexes and remained after adjustment.

Conclusions Particularly recurrent wheeze and a higher number of respiratory symptoms may predict lower lung function also in the long run among women and men with asthma.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2021
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-86694 (URN)10.1136/bmjresp-2021-000981 (DOI)000688483700001 ()34281917 (PubMedID)2-s2.0-85110821697 (Scopus ID)
Funder
Swedish Heart Lung FoundationSwedish Research CouncilNorrbotten County CouncilSwedish Asthma and Allergy AssociationVisare Norr
Note

Validerad;2021;Nivå 2;2021-08-17 (alebob);

Forskningsfinansiär: Nordic council; ALF – a regional agreement between Umeå University and Norrbotten County Council

Available from: 2021-08-17 Created: 2021-08-17 Last updated: 2022-03-14Bibliographically approved
Schyllert, C., Andersson, M., Backman, H., Lindberg, A., Rönmark, E. & Hedman, L. (2021). Childhood onset asthma is associated with lower educational level in young adults – A prospective cohort study. Respiratory Medicine, 186, Article ID 106514.
Open this publication in new window or tab >>Childhood onset asthma is associated with lower educational level in young adults – A prospective cohort study
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2021 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 186, article id 106514Article in journal (Refereed) Published
Abstract [en]

Background

Asthma is associated with low socioeconomic status among both children and adults, and adolescents with asthma report more school absenteeism than those without. However, it is unclear whether asthma in childhood and adolescence affects socioeconomic status in adulthood.

Methods

Within the Obstructive Lung disease In Northern Sweden Studies, all children in grade 1 and 2 in three municipalities were invited to a questionnaire survey, 97% participated (n=3430). They were followed annually until age 19, and thereafter at age 28 years. In this study, participants at ages 8y, 12y, 19y and 28y (n=2017) were included. Asthma was categorized into childhood onset (up to age 12y) and adolescent onset (from 12 to 19y). Data for assessment of socioeconomic status was collected at 28y and included educational level, occupation, and occupational exposure to gas, dust and/or fumes (GDF).

Results

Childhood onset asthma was associated with having compulsory school as the highest educational level at age 28y, also after adjustment for sex, smoking and BMI at age 19y and socioeconomic factors in childhood (OR 4.84 95%CI 2.01-11.65), and the pattern was the same among men and women. However, we found no significant associations between asthma in childhood or adolescence and socioeconomic groups, occupational groups or occupational exposure to GDF at age 28y.

Conclusions

Even though asthma in high-income countries, such as Sweden, is well recognised and treated, this study highlight that childhood onset asthma may have a negative long-term effect with regard to educational level in young adulthood.

Place, publisher, year, edition, pages
Elsevier, 2021
Keywords
Asthma, Social determinants of health, Occupational exposure, Educational status, Socioeconomic factors
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-86053 (URN)10.1016/j.rmed.2021.106514 (DOI)000698622400004 ()34198167 (PubMedID)2-s2.0-85108790578 (Scopus ID)
Funder
Swedish Heart Lung FoundationSwedish Asthma and Allergy AssociationVårdal FoundationRegion VästerbottenNorrbotten County CouncilVisare Norr
Note

Validerad;2021;Nivå 2;2021-07-08 (alebob);

Finansiär: Konsul Th C Berghs Stiftelse; Umeå University

Available from: 2021-06-28 Created: 2021-06-28 Last updated: 2022-03-16Bibliographically approved
Axelsson, M., Ilmarinen, P., Backman, H., Ekerljung, L., Hedman, L., Langhammer, A., . . . Rönmark, E. (2021). Differences in diagnostic patterns of obstructive airway disease between areas and sex in Sweden and Finland: The Nordic EpiLung Study. Journal of Asthma, 58(9), 1196-1207
Open this publication in new window or tab >>Differences in diagnostic patterns of obstructive airway disease between areas and sex in Sweden and Finland: The Nordic EpiLung Study
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2021 (English)In: Journal of Asthma, ISSN 0277-0903, E-ISSN 1532-4303, Vol. 58, no 9, p. 1196-1207Article in journal (Refereed) Published
Abstract [en]

Objective: To investigate the current prevalence of physician-diagnosed obstructive airway diseases by respiratory symptoms and by sex in Sweden and Finland. Method: In 2016, a postal questionnaire was answered by 34,072 randomly selected adults in four study areas: Västra Götaland and Norrbotten in Sweden, and Seinäjoki-Vaasa and Helsinki in Finland. Results: The prevalence of asthma symptoms was higher in Norrbotten (13.2%), Seinäjoki-Vaasa (14.8%) and Helsinki (14.4%) than in Västra Götaland (10.7%), and physician-diagnosed asthma was highest in Norrbotten (13.0%) and least in Västra Götaland (10.1%). Chronic productive cough was most common in the Finnish areas (7.7-8.2 % versus 6.3-6.7 %) while the prevalence of physician-diagnosed chronic bronchitis (CB) or chronic obstructive pulmonary disease (COPD) varied between 1.7-2.7% in the four areas. Among individuals with respiratory symptoms, the prevalence of asthma was most common in Norrbotten, while a diagnosis of COPD or CB was most common in Västra Götaland and Seinäjoki-Vaasa. More women than men with respiratory symptoms reported a diagnosis of asthma in Sweden and Seinäjoki-Vaasa but there were no sex differences in Helsinki. In Sweden, more women than men with symptoms of cough or phlegm reported a diagnosis of CB or COPD, while in Finland the opposite was found. Conclusion: The prevalence of respiratory symptoms and corresponding diagnoses varied between and within the countries. The proportion reporting a diagnosis of obstructive airway disease among individuals with respiratory symptoms varied, indicating differences in diagnostic patterns both between areas and by sex.

Place, publisher, year, edition, pages
Taylor & Francis, 2021
Keywords
asthma, COPD, chronic bronchitis, epidemiology, diagnostic practices, obstructive lung disease, respiratory symptoms, sex differences
National Category
Nursing
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-79247 (URN)10.1080/02770903.2020.1776727 (DOI)000545839200001 ()32475292 (PubMedID)2-s2.0-85087039697 (Scopus ID)
Funder
NordForskSwedish Heart Lung FoundationNorrbotten County CouncilSwedish Asthma and Allergy AssociationVisare Norr
Note

Validerad;2021;Nivå 2;2021-08-17 (alebob);

Forskningsfinansiär: ALF – a regional agreement between Umeå University and Norrbotten County Council; Herman Krefting Foundation for asthma and allergy research; Tampere Tuberculosis Foundation;  Finnish Anti-Tuberculosis Association Foundation; Competitive State Research Financing of the Expert Responsibility Area of Tampere University Hospital; Medical Research Fund of Seinäjoki Central Hospital; Nummela Sanatorium Foundation; Ida Montin Foundation; Helsinki University Central Hospital (TYH 2013354)

Available from: 2020-06-08 Created: 2020-06-08 Last updated: 2021-08-17Bibliographically approved
Hedman, L., Galanti, M., Ryk, L., Gilljam, H. & Adermark, L. (2021). Electronic cigarette use and smoking cessation in cohort studies and randomized trials: A systematic review and meta-analysis. Tobacco Prevention & Cessation, 7(62), Article ID 142320.
Open this publication in new window or tab >>Electronic cigarette use and smoking cessation in cohort studies and randomized trials: A systematic review and meta-analysis
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2021 (English)In: Tobacco Prevention & Cessation, ISSN 2459-3087, Vol. 7, no 62, article id 142320Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim of this systematic review and meta-analysis was to assess the association between e-cigarette use and subsequent smoking cessation in cohort studies and randomized controlled trials (RCT).

Methods: A systematic literature search was finalized 11 November 2019 using EMBASE, Cochrane Library, Scopus, PubMed Health, NICE evidence search, PROSPERO, CRD, PsycInfo, and PubMed including Medline. Inclusion criteria were: reporting empirical results; longitudinal observational design with a minimum of 3 months of follow-up; including general population samples; and allowing for comparison between users and non-users of e-cigarettes. Studies rated as having high risk of bias were excluded. The procedures described by PRISMA were followed, and the quality of evidence was rated using GRADE.

Results: Twenty-eight longitudinal, peer-reviewed publications from 26 cohort studies, and eight publications from seven RCTs assessing the association between e-cigarette use and smoking cessation were included in this review. A randomeffects meta-analysis based on 39147 participants in cohort studies showed a pooled unadjusted odds ratio (OR) for smoking cessation among baseline e-cigarette users compared with baseline non-users of 0.97 (95% CI: 0.67–1.40), while the adjusted OR was 0.90 (95% CI: 0.63–1.27). The pooled odds ratio for smoking cessation in RCTs was 1.78 (95% CI: 1.41–2.25). The evidence for cohort studies was graded as very low and for RCTs as low.

Conclusions: We did not find quality evidence for an association between e-cigarette use and smoking cessation. Although RCTs tended to support a more positive association between e-cigarette use and smoking cessation than the cohort studies, the grading of evidence was consistently low.

Place, publisher, year, edition, pages
European Network for Smoking and Tobacco Prevention, 2021
Keywords
electronic cigarettes, smoking cessation, quit smoking, systematic review, cohort, randomized, controlled trial
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-87646 (URN)10.18332/tpc/142320 (DOI)000707570300001 ()34712864 (PubMedID)2-s2.0-85120179239 (Scopus ID)
Funder
Public Health Agency of Sweden Norrbotten County Council, NLL-933163Swedish Research Council, 2018-0258
Note

Validerad;2021;Nivå 2;2021-10-26 (beamah);

Forskningsfinansiär: The Swedish Agency for Health Technology Assessment and Assessment of Social Services (SBU); The Swedish Heart-Lung Foundation (20200765, 20200750, 20170696, 20170438); a regional agreement between Umeå University and Västerbotten County Council (RV-738451)

Available from: 2021-10-26 Created: 2021-10-26 Last updated: 2021-12-13Bibliographically approved
Räisänen, P., Backman, H., Hedman, L., Andersson, M., Stridsman, C., Kankaanranta, H., . . . Rönmark, E. (2021). High but stable incidence of adult-onset asthma in northern Sweden over the last decades. ERJ Open Research, 7(3), Article ID 00262-2021.
Open this publication in new window or tab >>High but stable incidence of adult-onset asthma in northern Sweden over the last decades
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2021 (English)In: ERJ Open Research, E-ISSN 2312-0541, Vol. 7, no 3, article id 00262-2021Article in journal (Refereed) Published
Abstract [en]

Background: The prevalence of asthma has increased both among children and adults during the latter half of the 20th century. The prevalence among adults is affected by the incidence of asthma not only in childhood but also in adulthood. Time trends in asthma incidence have been poorly studied.

Aims: The aim of this study was to review the incidence of adult-onset asthma from 1996 to 2006 and 2006 to 2016 and compare the risk factor patterns.

Methods: In the Obstructive Lung Disease in Northern Sweden (OLIN) studies, two randomly selected population-based samples in the 20-69-year age group participated in postal questionnaire surveys about asthma in 1996 (n=7104, 85%) and 2006 (n=6165, 77%). A 10-year follow-up of the two cohorts with the same validated questionnaire was performed, and 5709 and 4552 responded, respectively. Different definitions of population at risk were used in the calculations of asthma incidence. The protocol followed a study performed between 1986 and 1996 in the same area.

Results: The crude incidence rate of physician-diagnosed asthma was 4.4 per 1000 person-years (men 3.8, women 5.5) from 1996 to 2006, and 4.8 per 1000 person-years (men 3.7, women 6.2) from 2006 to 2016. When correcting for possible under-diagnosis at study entry, the incidence rate was 2.4 per 1000 person-years from 1996 to 2006 and 2.6 per 1000 person-years from 2006 to 2016. The incidence rates were similar across age groups. Allergic rhino-conjunctivitis was the main risk factor for incident asthma in both observation periods (risk ratio 2.4-2.6).

Conclusions: The incidence of adult-onset asthma has been stable over the last two decades and has remained at a similar level since the 1980s. The high incidence contributes to the increase in asthma prevalence.

Place, publisher, year, edition, pages
European Respiratory Society, 2021
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-86682 (URN)10.1183/23120541.00262-2021 (DOI)000684273900035 ()34235212 (PubMedID)2-s2.0-85114081266 (Scopus ID)
Funder
Swedish Heart Lung FoundationSwedish Asthma and Allergy AssociationVisare NorrNorrbotten County Council
Note

Validerad;2021;Nivå 2;2021-08-18 (alebob);

Forskningsfinansiär: ALF, a regional agreement between Umeå University and Västerbotten and Norrbotten County Council

Available from: 2021-08-17 Created: 2021-08-17 Last updated: 2022-11-16Bibliographically approved
Adermark, L., Galanti, M. R., Ryk, C., Gilljam, H. & Hedman, L. (2021). Prospective association between use of electronic cigarettes and use of conventional cigarettes: a systematic review and meta-analysis. ERJ Open Research, 7(3), 00976-2020
Open this publication in new window or tab >>Prospective association between use of electronic cigarettes and use of conventional cigarettes: a systematic review and meta-analysis
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2021 (English)In: ERJ Open Research, E-ISSN 2312-0541, Vol. 7, no 3, p. 00976-2020Article in journal (Refereed) Published
Abstract [en]

Objective The aim of this systematic review and meta-analysis was to assess the association between e-cigarette use and subsequent initiation or recurrence of cigarette smoking.Data sources A systematic literature search was finalised on 11 November 2019 using PubMed (including MEDLINE), EMBASE, Cochrane Library, Scopus, PubMed Health, NICE Evidence Search, PROSPERO, CRD and PsycInfo.Study selection Studies were included if meeting the following criteria: reporting empirical results; longitudinal observational design with a minimum of 3 months of follow-up; including general population samples; allowing for the comparison between users and nonusers of e-cigarettes. Studies rated as having high risk of bias were excluded. Studies were independently assessed by at least two authors. The procedures described by PRISMA were followed, and the quality of evidence was rated using GRADE.Data synthesis 30 longitudinal studies from 22 different cohorts assessing e-cigarette use among nonsmokers or never-smokers at baseline, and subsequent use of cigarette smoking at follow-up, were included in this review. A random-effects meta-analysis based on 89 076 participants showed a pooled unadjusted odds ratio (OR) of cigarette smoking among baseline nonsmoker e-cigarette users compared with nonusers of 4.68 (CI 3.64–6.02), while the adjusted OR was 3.37 (CI 2.68–4.24). These results were consistent irrespective of whether the outcome was measured as ever-smoking or as past 30-day smoking. The evidence was graded as moderate.Conclusions Use of e-cigarettes may predict the initiation or recurrence of cigarette smoking.

Place, publisher, year, edition, pages
European Respiratory Society (ERS), 2021
National Category
Respiratory Medicine and Allergy
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-86693 (URN)10.1183/23120541.00976-2020 (DOI)000684273900052 ()34262971 (PubMedID)2-s2.0-85114067359 (Scopus ID)
Note

Validerad;2021;Nivå 2;2021-08-17 (johcin)

Available from: 2021-08-17 Created: 2021-08-17 Last updated: 2021-12-13Bibliographically approved
Almqvist, L., Backman, H., Stridsman, C., Lindberg, A., Lundbäck, B., Rönmark, E. & Hedman, L. (2020). Clinical outcome of adult onset asthma in a 15 year follow-up. Paper presented at ERS International Congress, 6-9 September, 2020, Virtual. European Respiratory Journal, 56(Suppl 64), Article ID 1396.
Open this publication in new window or tab >>Clinical outcome of adult onset asthma in a 15 year follow-up
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2020 (English)In: European Respiratory Journal, ISSN 0903-1936, E-ISSN 1399-3003, Vol. 56, no Suppl 64, article id 1396Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Background: Adult onset asthma is poorly studied and there are few long-term clinical follow-up studies.

Aim: To study clinical characteristics of adult onset asthma in a 15-year follow-up.

Method: Within the Obstructive Lung Disease in Northern Sweden (OLIN) studies, a cohort of n=309 subjects with adult onset asthma (aged 20-60 years) was recruited during 1995-99. The cohort was followed up in 2012-14 (n=205). Structured interviews and clinical examinations including spirometry were performed at both recruitment and follow-up. Skin prick tests were performed at recruitment and blood samples for cell counts and IgE at the follow-up. Asthma control was classified according to GINA 2006.

Results: At follow-up n=182 (89%) still had asthma, while n=23 (11%) were in remission. Among individuals with persistent asthma, mean pre-bronchodilator FEV1 percent of predicted was 89.0 at follow-up, similar as recruitment 88.3. At recruitment 16.5% were smokers, and of these, 86.7% had quit smoking at follow-up. At follow-up, 39% had blood neutrophils ≥4.0x109/L, 23% had blood eosinophils ≥0.3x109/L, and 28% had specific IgE>0.35 IU/ml to any airborne allergen. Any respiratory symptoms were reported by 90% and 31% used medium or high dose inhaled corticosteroids (ICS), 20% low dose ICS whereas 20% had no treatment. 55% had controlled asthma, 32% partly controlled and 13% uncontrolled asthma.

Conclusion: In this 15-year follow-up of adult onset asthma, the majority had persistent asthma. Smoking and high proportion using ICS may contribute to the stable lung function. Still, it should be noted that merely around every other had well controlled asthma.

Place, publisher, year, edition, pages
European Respiratory Society (ERS), 2020
National Category
Nursing
Research subject
Nursing
Identifiers
urn:nbn:se:ltu:diva-82894 (URN)10.1183/13993003.congress-2020.1396 (DOI)000606501402362 ()
Conference
ERS International Congress, 6-9 September, 2020, Virtual
Note

Godkänd;2021;Nivå 0;2021-02-11 (alebob)

Available from: 2021-02-11 Created: 2021-02-11 Last updated: 2021-02-11Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0002-1630-3167

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