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Brain tumor modeling: glioma growth and interaction with chemotherapy
Tehran University of Medical Science.
Tehran University of Medical Science.
Tehran University of Medical Science.
University of Tehran.
Vise andre og tillknytning
Rekke forfattare: 52011 (engelsk)Inngår i: Proceedings of SPIE, the International Society for Optical Engineering, ISSN 0277-786X, E-ISSN 1996-756X, Vol. 8285Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In last decade increasingly mathematical models of tumor growths have been studied, particularly on solid tumors which growth mainly caused by cellular proliferation. In this paper we propose a modified model to simulate the growth of gliomas in different stages. Glioma growth is modeled by a reaction-advection-diffusion. We begin with a model of untreated gliomas and continue with models of polyclonal glioma following chemotherapy. From relatively simple assumptions involving homogeneous brain tissue bounded by a few gross anatomical landmarks (ventricles and skull) the models have been expanded to include heterogeneous brain tissue with different motilities of glioma cells in grey and white matter. Tumor growth is characterized by a dangerous change in the control mechanisms, which normally maintain a balance between the rate of proliferation and the rate of apoptosis (controlled cell death). Result shows that this model closes to clinical finding and can simulate brain tumor behavior properly.

sted, utgiver, år, opplag, sider
2011. Vol. 8285
HSV kategori
Forskningsprogram
Experimentell mekanik
Identifikatorer
URN: urn:nbn:se:ltu:diva-32986DOI: 10.1117/12.913432Lokal ID: 7b02a502-9fea-4067-8afc-68d9aa565e94OAI: oai:DiVA.org:ltu-32986DiVA, id: diva2:1006221
Konferanse
International Conference on Graphic and Image Processing (ICGIP 2011) : 01/10/2011
Tilgjengelig fra: 2016-09-30 Laget: 2016-09-30 Sist oppdatert: 2017-11-30bibliografisk kontrollert

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