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Buccal delivery of small molecules and biologics: of mucoadhesive polymers, films, and nanoparticles
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago .ORCID-id: 0000-0002-3190-2168
UCD School of Veterinary Medicine and UCD Conway Institute, University College Dublin.
2017 (engelsk)Inngår i: Current opinion in pharmacology (Print), ISSN 1471-4892, E-ISSN 1471-4973, Vol. 36, s. 22-28Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Buccal delivery of macromolecules (biologics) sets a great challenge for researchers. Although several niche small molecule products have been approved as simple sprays, tablets and oral films, it is not simply a case of adapting existing technologies to biologics. Buccal delivery of insulin has reached clinical trials with two approaches: oromucosal sprays of the peptide with permeation enhancers, and embedded gold nanoparticles in a dissolvable film. However, neither of these approaches have led to FDA approvals likely due to poor efficacy, submaximal peptide loading in the dosage form, and to wide intra-subject variability in pharmacokinetics and pharmacodynamics. It is likely however that printed film designs with lower molecular weight stable biotech payloads including lipophilic glucagon-like 1 (GLP-1) agonists and macrocycles with long half-lives will generate greater efficacy than was achieved to date for insulin.

sted, utgiver, år, opplag, sider
Elsevier, 2017. Vol. 36, s. 22-28
HSV kategori
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Hälsovetenskap
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URN: urn:nbn:se:ltu:diva-65107DOI: 10.1016/j.coph.2017.07.011ISI: 000419665100006PubMedID: 28800417Scopus ID: 2-s2.0-85026830309OAI: oai:DiVA.org:ltu-65107DiVA, id: diva2:1133383
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Validerad; 2017; Nivå 2; 2017-08-15 (andbra)

Tilgjengelig fra: 2017-08-15 Laget: 2017-08-15 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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