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Formation of cocrystals from stoichiometric solutions of incongruently saturating systems by spray drying
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-6050-0432
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
2010 (engelsk)Inngår i: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 10, nr 8, s. 3302-3305Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Spray drying is a well established technique for material processing and scale-up. This study investigated the formation of pharmaceutical cocrystals by spray drying. The cocrystal formation mechanisms in spray-drying and solution methods, based on triangular phase diagrams, are discussed. The solvent evaporation of stoichiometric solutions of incongruently saturating cocrystals resulted in a mixture of phases, as dictated by the thermodynamic phase diagram. In contrast, spray drying of similar solutions of incongruently saturating systems generated pure cocrystals. It is thus suggested that the formation of cocrystals by spray drying could be kinetically controlled and/or mediated by the glassy state of the material.

sted, utgiver, år, opplag, sider
2010. Vol. 10, nr 8, s. 3302-3305
HSV kategori
Forskningsprogram
Hälsovetenskap
Identifikatorer
URN: urn:nbn:se:ltu:diva-7596DOI: 10.1021/cg100451qISI: 000280471700002Scopus ID: 2-s2.0-77955338170Lokal ID: 5fb42e60-a6cb-11df-a707-000ea68e967bOAI: oai:DiVA.org:ltu-7596DiVA, id: diva2:980486
Merknad
Validerad; 2010; 20100813 (ysko)Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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