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Serum/plasma methylmercury determination by isotope dilution gas chromatography: inductively coupled plasma mass spectrometry
ALS Scandinavia AB.
Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Geovetenskap och miljöteknik.ORCID-id: 0000-0002-4732-7348
Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Geovetenskap och miljöteknik.ORCID-id: 0000-0003-4505-4590
Vise andre og tillknytning
2011 (engelsk)Inngår i: Analytica Chimica Acta, ISSN 0003-2670, E-ISSN 1873-4324, Vol. 701, nr 2, s. 134-138Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A method for the determination of methylmercury in plasma and serum samples was developed. The method uses isotope dilution with 198Hg-labelled methylmercury, extraction into dichloromethane, back-extraction into water, aqueous-phase ethylation, purge and trap collection, thermal desorption, separation by gas chromatography, and mercury isotope specific detection by inductively coupled plasma mass spectrometry. By spiking 2 mL sample with 1.2 ng tracer, measurements in a concentration interval of (0.007–2.9) μg L−1 could be performed with uncertainty amplification factors <2. A limit of quantification of 0.03 μg L−1 was estimated at 10 times the standard deviation of concentrations measured in preparation blanks. Within- and between-run relative standard deviations were <10% at added concentration levels of 0.14 μg L−1, 0.35 μg L−1 and 2.8 μg L−1, with recoveries in the range 82% to 110%. Application of the method to 50 plasma/serum samples yielded a median (mean; range) concentration of methylmercury of 0.081 (0.091; <0.03–0.19) μg L−1. This is the first time methylmercury has been directly measured in this kind of specimen, and is therefore the first estimate of a reference range.

sted, utgiver, år, opplag, sider
2011. Vol. 701, nr 2, s. 134-138
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Forskningsprogram
Tillämpad geologi
Identifikatorer
URN: urn:nbn:se:ltu:diva-9918DOI: 10.1016/j.aca.2011.06.012ISI: 000294144400003PubMedID: 21801879Scopus ID: 2-s2.0-79960742571Lokal ID: 89f81c28-4778-4575-b596-e7ef287cb1daOAI: oai:DiVA.org:ltu-9918DiVA, id: diva2:982857
Merknad
Validerad; 2011; 20110620 (ysko)Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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Baxter, DouglasÖsterlund, HeleneRodushkin, Ilya

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