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A combined tactile and Raman probe for tissue characterization—design considerations
Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system. Department of Signals and Systems, Chalmers University of Technology, 412 96 Gothenburg, Sweden; MedTech West, Sahlgrenska University Hospital, Blå Stråket 7, 413 45 Gothenburg, Sweden.
Department of Applied Physics and Electronics, Umeå University, 901 87 Umeå, Sweden.
Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.ORCID-id: 0000-0003-3268-1691
Vise andre og tillknytning
2012 (engelsk)Inngår i: Measurement science and technology, ISSN 0957-0233, E-ISSN 1361-6501, Vol. 23, nr 6, artikkel-id 065901Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Histopathology is the golden standard for cancer diagnosis and involves the characterization of tissue components. It is labour intensive and time consuming. We have earlier proposed a combined fibre-optic near-infrared Raman spectroscopy (NIR-RS) and tactile resonance method (TRM) probe for detecting positive surgical margins as a complement to interoperative histopathology. The aims of this study were to investigate the effects of attaching an RS probe inside a cylindrical TRM sensor and to investigate how laser-induced heating of the fibre-optic NIR-RS affected the temperature of the RS probe tip and an encasing TRM sensor. In addition, the possibility to perform fibre-optic NIR-RS in a well-lit environment was investigated. A small amount of rubber latex was preferable for attaching the thin RS probe inside the TRM sensor. The temperature rise of the TRM sensor due to a fibre-optic NIR-RS at 270 mW during 20 s was less than 2 °C. Fibre-optic NIR-RS was feasible in a dimmed bright environment using a small light shield and automatic subtraction of a pre-recorded contaminant spectrum. The results are promising for a combined probe for tissue characterization.

sted, utgiver, år, opplag, sider
2012. Vol. 23, nr 6, artikkel-id 065901
Emneord [en]
tactile sensor, Raman spectroscopy, biological tissue
HSV kategori
Forskningsprogram
Medicinsk teknik för hälsovård; Centrumbildning - Centrum för medicinsk teknik och fysik (CMTF)
Identifikatorer
URN: urn:nbn:se:ltu:diva-14652DOI: 10.1088/0957-0233/23/6/065901ISI: 000304187300025Scopus ID: 2-s2.0-84862059679Lokal ID: e11febed-b17a-406c-983e-8b9bcb17af5fOAI: oai:DiVA.org:ltu-14652DiVA, id: diva2:987625
Merknad

Validerad; 2012; 20120507 (mornyb)

Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2024-03-26bibliografisk kontrollert

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Nyberg, MorganCandefjord, StefanRamser, KerstinLindahl, Olof

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