Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Combining the tactile resonance method and Raman spectroscopy for tissue characterization towards prostate cancer detection
Luleå tekniska universitet, Institutionen för system- och rymdteknik, Signaler och system.
2011 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Prostate cancer (PCa) is the most common male cancer in Europe and the US, and only lung and colorectal cancer have a higher mortality among European men. In Sweden, PCa is the most common cause of cancer-related death for men.The overall aim of this thesis was to explore the need for new and complementary methods for PCa detection and to take the rst step towards a novel approach: combining the tactile resonance method (TRM) and Raman spectroscopy (RS). First, the main methods for PCa detection were reviewed. Second, to establish a robust protocol for RS experiments in vitro, the eects of snap-freezing and laser illumination on porcine prostate tissue were studied using RS and multivariate statistics. Third, measurements on porcine and human tissue were performed to compare the TRM and RS data via multivariate techniques, and to assess the accuracy of classifying healthy and cancerous tissue using a support vector machine algorithm.It was concluded through the literature review that the gold standard for PCa detection and diagnosis, the prostate specic antigen test and systematic biopsy, have low sensitivity and specicity. Indolent and aggressive tumors cannot be reliably dierentiated, and many men are therefore treated either unnecessarily or too late. Clinical benets of the state-of-the-art in PCa imaging - advanced ultrasound and MR techniques - have still not been convincingly shown. There is a need for complementary and cost-eective detection methods. TRM and RS are promising techniques, but hitherto their potential for PCa detection have only been investigated in vitro.In the RS study no evidence of tissue degradation due to 830 nm laser illumination at an irradiance of ∼3 · 1010 W m-2 were found. Snap-freezing and subsequent storage at -80° C gave rise to subtle but signicant changes in Raman spectra, most likely related to alterations in the protein structure. The major changes due to PCa do not seem to be related to the protein structure, hence snap-freezing may be applied in our experiments.The combined measurements on porcine and human prostate tissue showed that RS provided additional discriminatory power to TRM. The classication accuracy for healthy porcine prostate tissue, and for healthy and cancerous human prostate tissue, was > 73%. This shows the power of the support vector machine applied to the combined data.In summary, this work indicates that an instrument combining TRM and RS is a promising complementary method for PCa detection. Snap-freezing of samples may be used in future RS studies of PCa. A combined instrument could be used for tumor-border demarcation during surgery, and potentially for guiding prostate biopsies towards lesions suspicious for cancer. All of this should provide a more secure diagnosis and consequently more effcient treatment of the patient.

sted, utgiver, år, opplag, sider
Luleå: Luleå tekniska universitet, 2011. , s. 136
Serie
Doctoral thesis / Luleå University of Technology 1 jan 1997 → …, ISSN 1402-1544
HSV kategori
Forskningsprogram
Medicinsk teknik för hälsovård
Identifikatorer
URN: urn:nbn:se:ltu:diva-26333Lokal ID: dc4a4915-8ee5-4a72-902c-cad0a31d35ebISBN: 978-91-7439-252-4 (tryckt)OAI: oai:DiVA.org:ltu-26333DiVA, id: diva2:999495
Merknad
Godkänd; 2011; 20110406 (candstef); DISPUTATION Ämnesområde: Medicinsk teknik för hälsovård/Medical Technology in Health Care Opponent: Docent Tomas Jansson, Institutionen för elektrisk mätteknik och industriell elektroteknik, Lunds tekniska högskola Ordförande: Professor Olof Lindahl, Institutionen för system- och rymdteknik, Luleå tekniska universitet Tid: Onsdag den 1 juni 2011, kl 09.00 Plats: A109, Luleå tekniska universitetTilgjengelig fra: 2016-09-30 Laget: 2016-09-30 Sist oppdatert: 2017-11-24bibliografisk kontrollert

Open Access i DiVA

fulltekst(22233 kB)172 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 22233 kBChecksum SHA-512
42d58bff2be1550edf814dccc49ea092337ab721295986958c8394325f4ad9d33fae7d62c39418766977f257f77bcc29632cf6722fa669d6daf3903a1bf1fddf
Type fulltextMimetype application/pdf

Personposter BETA

Candefjord, Stefan

Søk i DiVA

Av forfatter/redaktør
Candefjord, Stefan
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 172 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

isbn
urn-nbn

Altmetric

isbn
urn-nbn
Totalt: 272 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf