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Binding of Aluminium(III)-Citrate Complexes, [Al3(H-1Cit)3(OH)]-4 and [Al3(H-1Cit)3(OH)4]-7, to Alzheimer's A-beta(1-40) Peptides: In situ Atomic Force, Electron Microscopy and Solid State 13C and 27Al NMR Studies
Luleå tekniska universitet, Institutionen för samhällsbyggnad och naturresurser, Industriell miljö- och processteknik.ORCID-id: 0000-0003-1067-7990
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2005 (Engelska)Ingår i: Sixth Keele Meeting on Aluminium: Aluminium Lithosphere to Biosphere (and Back), Centro de Estudos do Ambiente e Mar, Universidade de Aveiro , 2005, s. 16-Konferensbidrag, Meeting abstract (Övrigt vetenskapligt)
Abstract [en]

It is believed that Alzheimer's disease (AD) amyloid-β-peptide (Aβ) deposits contribute directly to the disease's progressive neurodegeneration. Aggregation cascade for Aβ peptides, its relevance to neurotoxicity in the course of AD, various factors modulating Aβ aggregation kinetics and experimental methods useful for these studies were recently discussed [1]. Al(III), Zn(II), Cu(II) and Fe(III) ions are often colocalized at the center of the core of Alzheimer's amyloid plaques [2] and are suggested to promote aggregation of physiological concentrations of Aβ [3]. It has also been suggested that Al can block calcium permeable putative Aβ-peptide channels in bilayer membranes [4]. Therefore studies of complexation of metal ions with Aβ-oligomers and fibrils are important in the search for the causes of and potential treatments for AD.We studied effects of highly soluble and biologically relevant aluminium(III)-citrate compounds, [Al3(H-1Cit)3(OH)]-4 and [Al3(H-1Cit)3(OH)4]-7, on the fibrillogenesis of Aβ(1-40). All resonances in 156.37 MHz 27Al and 90.52 MHz 13C MAS NMR spectra of powder Al(III)-citrate complexes were assigned. 27Al MAS NMR of dialysed samples of Aβ(1-40) co-incubated with the Al(III)-citrate complexes at different concentrations in TRIS buffer solutions, pH 7.4, shows that Al(III)-citrates bind to Aβ(1-40) as [Al3(H-1Cit)3(OH)]-4 and either accelerate ([Al3(H-1Cit)3(OH)]-4 complex) or retard ([Al3(H-1Cit)3(OH)4]-7 compound) aggregation of Aβ(1-40) as revealed by AFM. [1] ON Antzutkin, Magn. Reson. Chem. 42 (2004) 231; [2] MA Lovell et al., J. Neurol. Sci. 158 (1998) 47; Ch Exley et al., Al and Alzheimer's disease, Ch Exley (Ed)1998) 47; Ch Exley , Ch Exley (Ed) Elsevier Science, 2001, 421; [3] PW Mantyh et al., J. Neurochem. 61 (1993) 1171; [4] N Arispe et al, PNAS 90 (1993) 567.

Ort, förlag, år, upplaga, sidor
Centro de Estudos do Ambiente e Mar, Universidade de Aveiro , 2005. s. 16-
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Fysikalisk kemi Annan fysik
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Gränsytors kemi; Fysik
Identifikatorer
URN: urn:nbn:se:ltu:diva-32935Lokalt ID: 7987ee80-146b-11dc-b9f0-000ea68e967bOAI: oai:DiVA.org:ltu-32935DiVA, id: diva2:1006170
Konferens
Keele Meeting on Aluminium: Aluminium Lithosphere to Biosphere (and Back) 26/02/2005 - 02/03/2005
Anmärkning
Godkänd; 2005; 20070606 (ysko)Tillgänglig från: 2016-09-30 Skapad: 2016-09-30 Senast uppdaterad: 2018-04-26Bibliografiskt granskad

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http://www.keele.ac.uk/depts/ch/groups/aluminium/meeting2005/meeting2005.htm

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Antzutkin, OlegAlmqvist, Nils

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