Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
The Effect of Inkjet Printing over Polymeric Films as Potential Buccal Biologics Delivery Systems
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago.
Instituto de Salud Pública de Chile, Santiago.
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0003-2645-5719
Visa övriga samt affilieringar
2018 (Engelska)Ingår i: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 19, nr 8, s. 3376-3387Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The buccal mucosa appears as a promissory route for biologic drug administration, and pharmaceutical films are flexible dosage forms that can be used in the buccal mucosa as drug delivery systems for either a local or systemic effect. Recently, thin films have been used as printing substrates to manufacture these dosage forms by inkjet printing. As such, it is necessary to investigate the effects of printing biologics on films as substrates in terms of their physical and mucoadhesive properties. Here, we explored solvent casting as a conventional method with two biocompatible polymers, hydroxypropyl methylcellulose, and chitosan, and we used electrospinning process as an electrospun film fabrication of polycaprolactone fibers due to its potential to elicit mucoadhesion. Lysozyme was used as biologic drug model and was formulated as a solution for printing by thermal inkjet printing. Films were characterized before and after printing by mechanical and mucoadhesive properties, surface, and ultrastructure morphology through scanning electron microscopy and solid state properties by thermal analysis. Although minor differences were detected in micrographs and thermograms in all polymeric films tested, neither mechanical nor mucoadhesive properties were affected by these differences. Thus, biologic drug printing on films was successful without affecting their mechanical or mucoadhesive properties. These results open way to explore biologics loading on buccal films by inkjet printing, and future efforts will include further in vitro and in vivo evaluations.

Ort, förlag, år, upplaga, sidor
Springer, 2018. Vol. 19, nr 8, s. 3376-3387
Nationell ämneskategori
Annan hälsovetenskap
Forskningsämne
Hälsovetenskap
Identifikatorer
URN: urn:nbn:se:ltu:diva-69877DOI: 10.1208/s12249-018-1105-1ISI: 000452258500007PubMedID: 29934803Scopus ID: 2-s2.0-85048895366OAI: oai:DiVA.org:ltu-69877DiVA, id: diva2:1223782
Anmärkning

Validerad;2018;Nivå 2;2018-12-05 (svasva)

Tillgänglig från: 2018-06-26 Skapad: 2018-06-26 Senast uppdaterad: 2019-02-27Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Vuddanda, Parameswara RaoVelaga, SitaramMorales, Javier O.

Sök vidare i DiVA

Av författaren/redaktören
Vuddanda, Parameswara RaoVelaga, SitaramMorales, Javier O.
Av organisationen
Medicinsk vetenskap
I samma tidskrift
AAPS PharmSciTech
Annan hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 10 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf