Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Fabrication and characterization of novel bilayer scaffold from nanocellulose based aerogel for skin tissue engineering applications
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Department of Wood and Paper Sciences and Technology, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Marquette University, School of Dentistry, Milwaukee, WI, USA.
Luleå tekniska universitet, Institutionen för teknikvetenskap och matematik, Materialvetenskap.ORCID-id: 0000-0003-4762-2854
Visa övriga samt affilieringar
2019 (Engelska)Ingår i: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 136, s. 796-803Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The aim of this study was to fabricate a novel bilayer scaffold containing cellulose nanofiber/poly (vinyl) alcohol (CNF/PVA) to evaluate its potential use in skin tissue engineering. Here, the scaffolds were fabricated using a novel one-step freeze-drying technique with two different concentrations of the aforementioned polymers. FE-SEM analysis indicated that the fabricated scaffolds had interconnected pores with two defined pore size in each layer of the bilayer scaffolds that can recapitulate the two layers of the dermis and epidermis of the skin. Lower concentration of polymers causes higher porosity with larger pore size and increased water uptake and decreased mechanical strength. FTIR proved the presence of functional groups and strong hydrogen bonding between the molecules of CNF/PVA and the efficient crosslinking. The MTT assay showed that these nanofibrous scaffolds meet the requirement as a biocompatible material for skin repair. Here, for the first time, we fabricated bilayer scaffold using a novel one-step freeze-drying technique only by controlling the polymer concentration with spending less time and energy.

Ort, förlag, år, upplaga, sidor
Elsevier, 2019. Vol. 136, s. 796-803
Nyckelord [en]
Bilayered scaffold, Cellulose nanofiber (CNF), Freeze-drying, Skin tissue engineering
Nationell ämneskategori
Biomaterial
Forskningsämne
Trä och bionanokompositer
Identifikatorer
URN: urn:nbn:se:ltu:diva-75120DOI: 10.1016/j.ijbiomac.2019.06.104ISI: 000482533000080PubMedID: 31226370Scopus ID: 2-s2.0-85067698284OAI: oai:DiVA.org:ltu-75120DiVA, id: diva2:1332730
Anmärkning

Validerad;2019;Nivå 2;2019-06-28 (svasva)

Tillgänglig från: 2019-06-28 Skapad: 2019-06-28 Senast uppdaterad: 2019-09-13Bibliografiskt granskad

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Oksman, Kristiina

Sök vidare i DiVA

Av författaren/redaktören
Oksman, Kristiina
Av organisationen
Materialvetenskap
I samma tidskrift
International Journal of Biological Macromolecules
Biomaterial

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 14 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf