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Utility of Hansen solubility parameters in the cocrystal screening
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-6050-0432
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Vise andre og tillknytning
2010 (engelsk)Inngår i: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 62, nr 10 - Spec issue, s. 1360-1362Artikkel i tidsskrift, Meeting abstract (Annet vitenskapelig) Published
Abstract [en]

The objective of this study was to test if the miscibility between drug and coformer, as predicted by solubility parameters, can be used as a tool in the cocrystal research. Hansen Solubility Parameters (HSPs) of a model drug, indomethacin and thirty coformers were calculated according to the group contribution method. The distances in HSPs between indomethacin and each cocrystal former were then calculated using three validated miscibility tools. Twenty coformers were predicted and confirmed to be miscible with the drug. Interestingly, all cocrystals forming systems were miscible. Two new cocrystal systems were discovered through this approach. Therefore, the utility of the solubility parameters approach can enhance the effi ciency of cocrystal screening.

sted, utgiver, år, opplag, sider
2010. Vol. 62, nr 10 - Spec issue, s. 1360-1362
HSV kategori
Forskningsprogram
Hälsovetenskap
Identifikatorer
URN: urn:nbn:se:ltu:diva-38056Lokal ID: c52ffb80-cae2-11df-a707-000ea68e967bOAI: oai:DiVA.org:ltu-38056DiVA, id: diva2:1011555
Konferanse
UK Pharmsci Conference : 01/09/2010 - 03/09/2010
Merknad
Godkänd; 2010; 20100928 (ysko)Tilgjengelig fra: 2016-10-03 Laget: 2016-10-03 Sist oppdatert: 2018-05-31bibliografisk kontrollert

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