Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Chronic airway obstruction in a population-based adult asthma cohort: Prevalence, incidence and prognostic factors
Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, The OLIN Unit, Umeå University.
Department of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine/the OLIN Unit, Umeå University.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.ORCID-id: 0000-0001-6622-3838
Real-World Evidence&Epidemiology, GSK R&D.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 138, s. 115-122Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

Asthma and COPD may overlap (ACO) but information about incidence and risk factors are lacking. This study aimed to estimate prevalence, incidence and risk factors of chronic airway obstruction (CAO) in a population-based adult asthma cohort.

Methods

During 1986–2001 a large population-based asthma cohort was identified (n = 2055, 19-72y). Subsamples have participated in clinical follow-ups during the subsequent years. The entire cohort was invited to a clinical follow-up including interview, spirometry, and blood sampling in 2012–2014 when n = 983 subjects performed adequate spirometry. CAO was defined as post-bronchodilator FEV1/FVC<0.7.

Results

At study entry, asthmatics with prevalent CAO (11.4%) reported more respiratory symptoms, asthma medication use, and ischemic heart disease than asthmatics without CAO (asthma only). Subjects who developed CAO during follow-up (17.6%; incidence rate of 16/1000/year) had a more rapid FEV1 decline and higher levels of neutrophils than asthma only. Smoking, older age and male sex were independently associated with increased risk for both prevalent and incident CAO, while obesity had a protective effect.

Conclusions

In this prospective adult asthma cohort, the majority did not develop CAO. Smoking, older age and male sex were risk factors for prevalent and incident CAO, similar to risk factors described for COPD in the general population.

sted, utgiver, år, opplag, sider
Elsevier, 2018. Vol. 138, s. 115-122
HSV kategori
Forskningsprogram
Omvårdnad; Hälsovetenskap
Identifikatorer
URN: urn:nbn:se:ltu:diva-68195DOI: 10.1016/j.rmed.2018.03.036ISI: 000432442400017Scopus ID: 2-s2.0-85045212522OAI: oai:DiVA.org:ltu-68195DiVA, id: diva2:1195448
Merknad

Validerad;2018;Nivå 2;2018-04-13 (rokbeg)

Tilgjengelig fra: 2018-04-05 Laget: 2018-04-05 Sist oppdatert: 2018-06-08bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstScopus

Personposter BETA

Stridsman, CarolineHedman, Linnea

Søk i DiVA

Av forfatter/redaktør
Stridsman, CarolineHedman, Linnea
Av organisasjonen
I samme tidsskrift
Respiratory Medicine

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 67 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf