Adaptive neuro-fuzzy inference systems (ANFIS) in combination with genetic algorithm (GA); provide valuable modeling approaches of complex systems for a wide range of coal samples. Evaluation of this combination (GA-ANFIS) showed that the GA-ANFIS approach can be utilized as an efficient tool for describing and estimating some of coal variables such as Hardgrove grindability index, gross calorific value, free swelling index, and maximum vitrinite reflectance with various coal analyses (proximate, ultimate, elemental, and petrographic analysis). Statistical factors (correlation coefficient, mean square error, and variance accounted for) and differences between actual and predicted values demonstrated that the GA-ANFIS can be applied successfully, and provide high accuracy for prediction of those coal variables.