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Severe asthma: A population study perspective
Dept of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, the OLIN unit, Umeå university, Umeå, Sweden.
Dept of Public Health and Clinical Medicine, Division of Occupational and Environmental Medicine, the OLIN unit, Umeå university, Umeå, Sweden.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad.ORCID-id: 0000-0001-6622-3838
Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden, 4 Dept of Internal Medicine, Cen tral County Hospital of Halland, Halmstad, Sweden.
Vise andre og tillknytning
2019 (engelsk)Inngår i: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 49, nr 6, s. 819-828Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BackgroundSevere asthma is a considerable challenge for patients, health care professionals and society. Few studies have estimated the prevalence of severe asthma according to modern definitions of which none based on a population study.

ObjectiveTo describe characteristics and estimate the prevalence of severe asthma in a large adult population‐based asthma cohort followed for 10‐28 years.

MethodsN=1006 subjects with asthma participated in a follow‐up during 2012‐14, when 830 (mean age 59y, 56% women) still had current asthma. Severe asthma was defined according to three internationally well‐known criteria: the ATS workshop definition from 2000 used in the US Severe Asthma Research Program (SARP), the 2014 ATS/ERS Task force definition and the GINA 2017. All subjects with severe asthma according to any of these criteria were undergoing respiratory specialist care, and were also contacted by telephone to verify treatment adherence.

ResultsThe prevalence of severe asthma according to the three definitions was 3.6% (US SARP), 4.8% (ERS/ATS Taskforce), and 6.1% (GINA) among subjects with current asthma. Although all were using high ICS doses and other maintenance treatment, >40% had uncontrolled asthma according to the asthma control test. Severe asthma was related to age >50 years, nasal polyposis, impaired lung function, sensitization to aspergillus, and tended to be more common in women. Further, neutrophils in blood significantly discriminated severe asthma from other asthma.

Conclusions and clinical relevanceSevere asthma differed significantly from other asthma in terms of demographic, clinical and inflammatory characteristics, results suggesting possibilities for improved treatment regimens of severe asthma. The prevalence of severe asthma in this asthma cohort was 4‐6%, corresponding to approximately 0.5% of the general population.

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2019. Vol. 49, nr 6, s. 819-828
Emneord [en]
epidemiology, asthma, eosinophils, neutrophils, IgE, lung function
HSV kategori
Forskningsprogram
Omvårdnad
Identifikatorer
URN: urn:nbn:se:ltu:diva-73200DOI: 10.1111/cea.13378ISI: 000475694600009PubMedID: 30817038Scopus ID: 2-s2.0-85066803309OAI: oai:DiVA.org:ltu-73200DiVA, id: diva2:1296307
Merknad

Validerad;2019;Nivå 2;2019-07-11 (johcin)

Tilgjengelig fra: 2019-03-14 Laget: 2019-03-14 Sist oppdatert: 2019-08-20bibliografisk kontrollert

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