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Acute Effects of Electronic Cigarette Inhalation on the Vasculature and the Conducting Airways
Division of Internal Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden.
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Omvårdnad. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, The OLIN Unit, Umeå University, Umeå, Sweden.ORCID-id: 0000-0002-1630-3167
Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockholm, Sweden.
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2019 (Engelska)Ingår i: Cardiovascular Toxicology, ISSN 1530-7905, E-ISSN 1559-0259Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

The use of electronic cigarettes has increased exponentially since its introduction onto the global market in 2006. However, short- and long-term health effects remain largely unknown due to the novelty of this product. The present study examines the acute effects of e-cigarette aerosol inhalation, with and without nicotine, on vascular and pulmonary function in healthy volunteers. Seventeen healthy subjects inhaled electronic cigarette aerosol with and without nicotine on two separate occasions in a double-blinded crossover fashion. Blood pressure, heart rate, and arterial stiffness measured by pulse wave velocity and pulse wave analysis were assessed at baseline, and then at 0 h, 2 h, and 4 h following exposure. Dynamic spirometry and impulse oscillometry were measured following vascular assessments at these time points, as well as at 6 h following exposure. e-Cigarette aerosol with nicotine caused a significant increase in heart rate and arterial stiffness. Furthermore, e-cigarette aerosol-containing nicotine caused a sudden increase in flow resistance as measured by impulse oscillometry, indicating obstruction of the conducting airways. Both aerosols caused an increase in blood pressure. The present study indicates that inhaled e-cigarette aerosol with nicotine has an acute impact on vascular and pulmonary function. Thus, chronic usage may lead to long-term adverse health effects. Further investigation is warranted.

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2019.
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Arterial stiffness, Augmentation index, ENDS, Electronic cigarettes, IOS, Pulse wave velocity, e-Cig
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URN: urn:nbn:se:ltu:diva-73559DOI: 10.1007/s12012-019-09516-xPubMedID: 30963443OAI: oai:DiVA.org:ltu-73559DiVA, id: diva2:1303751
Tillgänglig från: 2019-04-10 Skapad: 2019-04-10 Senast uppdaterad: 2019-04-10

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