Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Silodosin oral films: Development, physico-mechanical properties and in vitro dissolution studies in simulated saliva
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap. College of Pharmacy, University of Mosul, Mosul, Iraq.ORCID-id: 0000-0002-2273-457x
Research Centre for Topical Drug Delivery and Toxicology, Department of Clinical and Pharmaceutical Sciences, School of Life and Medical Sciences, University of Hertfordshire, UK.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
2019 (engelsk)Inngår i: Journal of Drug Delivery Science and Technology, ISSN 1773-2247, Vol. 53, artikkel-id 101122Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Sublingual film dosage forms for drugs used for fast symptomatic treatment have promise because they allow a rapid onset of action. The aim of this study was to prepare films of silodosin intended for sublingual administration for the symptomatic treatment of benign prostatic hyperplasia in men. Hydroxypropyl methylcellulose (HPMC) or hydroxypropyl methylcellulose acetate succinate (HPMC-AS) were used as film-forming polymers. The effects of the polymers and the surfactant tocopherol polyethylene glycol succinate (TPGS) on the physico-mechanical properties and dissolution behavior of the films in simulated saliva were investigated. The eight silodosin oral films developed (F1–F8) contained 8 mg silodosin per 6 cm2 film and HPMC or HPMC-AS in drug:polymer ratios of 1:5 or 1:3, while four also contained TPGS (0.5% w/w). The films were characterized using DSC, TGA, SEM, and PXRD and the mechanical properties were investigated by measuring tensile strength, elongation at break and Young's modulus. The mechanical properties of the films were dependent on the ratio of polymer used. The in vitro dissolution and drug release studies indicated that HPMC-AS films disintegrated more quickly than HPMC films. Silodosin was shown to be dispersed within the polymers. Despite silodosin being submicronized in the HPMC films, the dissolution and drug release rate (time for 80% release) from HPMC films was significantly faster than from HPMC-AS films. TPGS increased the drug release rate to a greater extent with HPMC than with HPMC-AS. The degree of saturation of formulation F4 was >1, which shows potential for improving oral absorption of silodosin.

sted, utgiver, år, opplag, sider
Elsevier, 2019. Vol. 53, artikkel-id 101122
Emneord [en]
Silodosin, Sublingual oral films, HPMC, HPMC-AS, TPGS, Simulated saliva
HSV kategori
Forskningsprogram
Hälsovetenskap
Identifikatorer
URN: urn:nbn:se:ltu:diva-75248DOI: 10.1016/j.jddst.2019.06.019ISI: 000487963600019OAI: oai:DiVA.org:ltu-75248DiVA, id: diva2:1335878
Merknad

Validerad;2019;Nivå 2;2019-07-08 (johcin)

Tilgjengelig fra: 2019-07-08 Laget: 2019-07-08 Sist oppdatert: 2019-10-18bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

AlHayali, AmaniVelaga, Sitaram

Søk i DiVA

Av forfatter/redaktør
AlHayali, AmaniVelaga, Sitaram
Av organisasjonen
I samme tidsskrift
Journal of Drug Delivery Science and Technology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 21 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf