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Pressure-assisted microsyringe 3D printing of oral films based on pullulan and hydroxypropyl methylcellulose
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems. Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.ORCID iD: 0000-0003-1304-3686
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science.ORCID iD: 0000-0002-4628-3857
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.ORCID iD: 0000-0002-0079-9049
Department of Pharmaceutics, UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
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2021 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 595, article id 120197Article in journal (Refereed) Published
Abstract [en]

Oral films (OFs) continue to attract attention as drug delivery systems, particularly for pedatric and geriatric needs. However, immiscibility between different polymers limits the full potential of OFs from being explored. One example is pullulan (PUL), a novel biopolymer which often has to be blended with other polymers to reduce cost and alter its mechanical properties. In this study, the state-of-the-art in fabrication techniques, three-dimensional (3D) printing was used to produce hybrid film structures of PUL and hydroxypropyl methylcellulose (HPMC), which were loaded with caffeine as a model drug. 3D printing was used to control the spatial deposition of films. HPMC was found to increase the mean mechanical properties of PUL films, where the tensile strength, elastic modulus and elongation break increased from 8.9 to 14.5 MPa, 1.17 to 1.56 GPa and from 1.48% to 1.77%, respectively. In addition, the spatial orientation of the hybrid films was also explored to determine which orientation could maximize the mechanical properties of the hybrid films. The results revealed that 3D printing could modify the mechanical properties of PUL whilst circumventing the issues associated with immiscibility.

Place, publisher, year, edition, pages
Elsevier, 2021. Vol. 595, article id 120197
Keywords [en]
3D printing, 3D printed drug products, Printing medicines and pharmaceuticals, Pressure Assisted Microsyringe, Oral drug delivery films, Rheology
National Category
Control Engineering Other Materials Engineering Other Medical Engineering
Research subject
Engineering Materials; Automatic Control; Medical Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-82638DOI: 10.1016/j.ijpharm.2021.120197ISI: 000615977600003PubMedID: 33486041Scopus ID: 2-s2.0-85099807137OAI: oai:DiVA.org:ltu-82638DiVA, id: diva2:1522531
Funder
The Kempe Foundations, SMK-1640ÅForsk (Ångpanneföreningen's Foundation for Research and Development), 18-459
Note

Validerad;2021;Nivå 2;2021-02-04 (alebob)

Available from: 2021-01-26 Created: 2021-01-26 Last updated: 2021-04-29Bibliographically approved

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Elbadawi, MohammedNikjoo, DariushGustafsson, Thomas

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