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The Effects of Working Memory Updating Training in Parkinson’s Disease: A Feasibility and Single-Subject Study on Cognition, Movement and Functional Brain Response
Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden.
Department of Psychology, Umeå University, Umeå, Sweden.
Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden. Department of Radiation Sciences, Umeå University, Umeå, Sweden. Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital, Hvidovre, Denmark. Institute of Sports Medicine Copenhagen (ISMC), Bispebjerg Hospital, Copenhagen University, Copenhagen, Denmark.
Department of Psychology, Umeå University, Umeå, Sweden.
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2021 (English)In: Frontiers in Psychology, E-ISSN 1664-1078, Vol. 11, article id 587925Article in journal (Refereed) Published
Abstract [en]

In Parkinson’s disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject (FL) study were performed in which patients with PD completed computerized WM updating training. The outcome measures were the pre-post changes in criterion and transfer cognitive tests; cognitive complaints; psychological health; movement kinematics; and task-related BOLD signal. Participants in the feasibility study showed improvements on the criterion tests at post-test. FL displayed the largest improvements on the criterion tests and smaller improvements on transfer tests. Furthermore, FL reported improved cognitive performance in everyday life. A shorter onset latency and smoother upper-limb goal-directed movements were measured at post-test, as well as increased activation within the striatum and decreased activation throughout the fronto-parietal WM network. This two-part study demonstrated that WM updating training is feasible to complete for PD patients and that change occurred in FL at post-test in the domains of cognition, movement and functional brain response.

Place, publisher, year, edition, pages
Frontiers Media S.A., 2021. Vol. 11, article id 587925
Keywords [en]
Parkinson’s disease, cognitive training, cognition, working memory, movement kinematics, functional magnetic resonance imaging
National Category
Production Engineering, Human Work Science and Ergonomics
Research subject
Engineering Psychology
Identifiers
URN: urn:nbn:se:ltu:diva-82811DOI: 10.3389/fpsyg.2020.587925ISI: 000612001800001PubMedID: 33519604Scopus ID: 2-s2.0-85100012546OAI: oai:DiVA.org:ltu-82811DiVA, id: diva2:1526409
Funder
Forte, Swedish Research Council for Health, Working Life and Welfare, 2014-1654Knut and Alice Wallenberg Foundation, KAW 2015.0192
Note

Validerad;2021;Nivå 2;2021-02-08 (alebob);

Finansiär: Swedish Parkinson Foundation

Available from: 2021-02-08 Created: 2021-02-08 Last updated: 2022-02-10Bibliographically approved

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Stigsdotter Neely, Anna

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