Within mineral comminution, the product properties (such as particle size distribution and mineral liberation characteristics) along with process efficiency are affected by material related and process environment factors. Understanding and optimizing these factors leads to designing and developing an energy-efficient process with a specified product. A better understanding of interactions between comminution environments and ore properties is the fundamental approach to improve the breakage process. This could lead to achieving a desired product particle size and liberation with the least energy consumption. It can even be used for designing new or improving the performance of comminution machines. In this doctoral thesis, breakage fundamentals are analyzed and set against the principles of various comminution machines: (i) Loading mechanism is defined as the physical action that is applied to a particle or several particles to introduce mechanical stress. (ii) The resulting pattern of the particle failure is referred to as breakage mechanism. (iii) The breakage mode defines the particle breakage and its dependence on ore texture and mineral liberation. To date, most of the research has addressed fragmentation and energy consumption within the comminution system. While optimizing these two factors is used as the approach to have an efficient process, improving mineral liberation is the other approach. In this regard, promoting the breakage mode to preferential in phase and phase boundary breakage could help to increase the liberation degree. According to the literature, mechanical stress is one of the factors controlling mineral liberation. While mechanical stresses are related to the comminution environment, ore texture is related to the particle's inherent characteristics. The thesis aims to identify ore textural micro features and combine them with micro-static and micro-dynamic processes as the key to achieve the most efficient process in terms of mineral liberation, fracture energy, and particle fragmentation. In the first stage of the work, iron oxide ore from the Malmberget mine in Northern Sweden was used and various ore textures were characterized on micro-level to attain the qualitative and quantitative features. These features were not only used for distinguishing textures but were also used later for data interpretation. In the second stage, two distinct ore textures were selected to investigate single particle breakage through four‐dimensional deformation and two‐dimensional crack quantification. The former method determines the breakage mode by quantifying internal deformation and strain in a three-dimensional volume of in-situ X-ray computed micro-tomography measurements. In the latter method, two-dimensional scanning electron microscopy - backscattered electron was used to quantify cracks based on the type of breakage mode. In addition, X-ray computed micro-tomography three-dimensional imaging was used in order to track the propagated cracks in the third dimension. Moreover, magnetite grains cracks were studied qualitatively based on optical microscopy images in order to identify and characterize the propagated cracks. In the third stage, multiple layers of particles of three hematite and three magnetite ore textures were fragmented at two displacement rates. The attained data in terms of breakage mode, liberation distribution, fragmented particles, and fracture energy were compared and their relation to micro-processes and micro-ore features were evaluated. In the fourth stage, multivariate data analysis was applied for finding and predicting patterns in mineral liberation, fracture energy, and fragmentation connected to ore texture features and displacement rate. Moreover, a comparison of ore textural features was also done to find the strongest factors. Finally, the optimal conditions to have the lowest fracture energy and highest liberation were investigated.