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Engineered microparticles of hyaluronic acid hydrogel for controlled pulmonary release of salbutamol sulphate
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Material Science. Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.ORCID iD: 0000-0002-4628-3857
Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.
Pharmaceutical Development, Orexo AB, 751 05, Uppsala, Sweden.
Department of Pharmaceutical Biosciences, Uppsala University, P.O. Box 591, 751 24 Uppsala, Sweden.ORCID iD: 0000-0003-4013-9704
2023 (English)In: International Journal of Pharmaceutics, ISSN 0378-5173, E-ISSN 1873-3476, Vol. 643, article id 123225Article in journal (Refereed) Published
Abstract [en]

Most pulmonary drugs are immediate-release formulations with short duration of action. Controlled release systems provide the ability to deliver drugs at a controlled rate, which helps maintain drug concentrations within the therapeutic window for a longer period of time. This study aimed to produce microparticles (MPs) of hyaluronic acid hydrogel (HAGA) loaded with salbutamol sulphate (SS) for controlled release in the lung. The drug-loaded MPs were prepared via spray drying and underwent extensive characterization, which revealed that SS was successfully encapsulated in the HAGA matrix. The prepared MPs (denoted as HASS) ranged in size from 1.6 ± 0.4 μm to 1.7 ± 0.5 μm with a fine particle fraction (FPF) of 48–56% and showed improvement in aerodynamic properties compared to unloaded HAGA hydrogel MPs. In vitro drug release studies performed in a Transwell system confirmed the potential of the particles to release the drug in a sustained manner. The drug release was delayed for all formulations, with a t63 between 5 and 30 min, compared to <1min for pure SS. This study advances our understanding of the formulation of a highly soluble drug to achieve controlled release in the lung.

Place, publisher, year, edition, pages
Elsevier, 2023. Vol. 643, article id 123225
Keywords [en]
Hyaluronic acid, Salbutamol sulphate, Hydrogel, Controlled release, Pulmonary
National Category
Pharmaceutical Sciences
Research subject
Engineering Materials
Identifiers
URN: urn:nbn:se:ltu:diva-99261DOI: 10.1016/j.ijpharm.2023.123225ISI: 001049344600001PubMedID: 37451326Scopus ID: 2-s2.0-85166569074OAI: oai:DiVA.org:ltu-99261DiVA, id: diva2:1786006
Funder
Vinnova, 2017-02690
Note

Godkänd;2023;Nivå 0;2023-08-07 (hanlid)

Available from: 2023-08-07 Created: 2023-08-07 Last updated: 2023-10-11Bibliographically approved

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Nikjoo, Dariush

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