Gold is widely recognized as a noble metal due to its inherent inertness in its bulk form. Nevertheless, gold exhibits reactivity in its ionic form. The inert qualities of bulk gold have led to its extensive recognition as a fundamental raw ingredient in several biomedical processes. These applications encompass drug delivery microchips, dental prostheses, reconstructive surgery, food additives, and endovascular stents. Gold in large amounts can be thought of as safe. Gold can also exist as molecules or ions, specifically gold ions, making it easier to make gold nanomaterials. The distinctive characteristics of gold set it apart from its molecular or bulk states, making its execution a very efficient instrument in the field of nanomedicine. Some of these traits are ease of synthesis, a higher ratio of surface area to volume, more reactive particles, the ability to withstand changes to the surface, and strong optical properties. The reduced reverse degree-based polynomials and topological descriptors of the molecular structure of the gold crystal are investigated in this manuscript. The numerical and graphical analysis of outcomes this study are also described.