Lifelong learning can be indispensable for the adaptation to continuously evolving labor markets and societal demands. In the current study, we examined psychological factors, notably aspects of personality (personality traits in the five-factor model and trait curiosity), self-reflection and motivation in relation to attitudes to lifelong learning. A specific aim was to examine the relative importance of these factors in their contribution to attitudes to lifelong learning. The study was carried out by use of a digital survey and included 717 adults (Mage = 47.93) within working life. The results showed that self-reflection and trait curiosity were the strongest predictors of attitudes to lifelong learning but work intrinsic motivation and openness to experience (a personality trait in the five-factor model) also contributed with unique explanatory power, although to a lesser degree. The results can inform individualized accessibility strategies for lifelong learning.