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In situ monitoring of antisolvent addition crystallization with principal components analysis of Raman spectra
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.
Departments of Chemistry, Chemical Engineering & Materials Science and Agricultural Engineering, Michigan State University, East Lansing, Michigan.
2004 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 4, no 3, p. 457-463Article in journal (Refereed) Published
Abstract [en]

Fiber optic Raman spectroscopy was used for in situ monitoring of antisolvent addition crystallization of progesterone. Raman spectral features of the solute and the antisolvent were subjected to principal components analysis (PCA) to attempt to obtain information that is not readily apparent from the raw spectral data. For the system utilized, PCA was able to distinguish spectral features from the solute in solution, the solute crystals, and the antisolvent. Furthermore, PCA was capable of detecting subtle changes in the spectral data (as the addition of antisolvent progressed) that could be used as a warning for the onset of crystallization. The current study demonstrates the advantages that can be gained by combining PCA with Raman spectroscopy for monitoring crystallizations in situ.

Place, publisher, year, edition, pages
2004. Vol. 4, no 3, p. 457-463
National Category
Bioprocess Technology
Research subject
Biochemical Process Engineering
Identifiers
URN: urn:nbn:se:ltu:diva-2953DOI: 10.1021/cg034206yISI: 000221267400008Scopus ID: 2-s2.0-2542551068Local ID: 0b2539f0-7b2f-11db-8824-000ea68e967bOAI: oai:DiVA.org:ltu-2953DiVA, id: diva2:975808
Note
Validerad; 2004; 20061123 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Berglund, Kris

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