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Pharmaceutical salts of fluoroquinolone antibacterial drugs with acesulfame sweetener
Luleå University of Technology, Department of Health Sciences, Medical Science.
Energy Technology and Thermal Process Chemistry, Umeå University.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
2012 (English)In: Molecular Crystals and Liquid Crystals, ISSN 1542-1406, E-ISSN 1563-5287, Vol. 562, no 1, p. 254-264Article in journal (Refereed) Published
Abstract [en]

Novel organic salts of norfloxacin and ciprofloxacin with artificial sweeteners such as saccharin and acesulfame were prepared. The two salts 1 and 2 were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Finally, the crystal structures were solved by single crystal X-ray diffraction data and the structures were analyzed in terms of supramolecular synthons. In norfloxacin acesulfamate 1, two norfloxacin cations and two acesulfame anions form an eight membered cyclic tetramer supramolecular synthon. The salt, ciprofloxacin acesulfamate 2, has a similar structure as salt 1. This study contributes the importance of crystal engineering and supramolecular chemistry to the pharmaceutical applications in terms of interactions and structural correlations in the design of new solid phases. Supplemental materials are available for this article. Go to the publisher's online edition of Molecular Crystals and Liquid Crystals to view the free supplemental file

Place, publisher, year, edition, pages
2012. Vol. 562, no 1, p. 254-264
National Category
Other Health Sciences
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Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-6357DOI: 10.1080/10426507.2012.669673ISI: 000307059000022Scopus ID: 2-s2.0-84864705708Local ID: 496bb0cd-98fc-4d80-9c67-5066333af219OAI: oai:DiVA.org:ltu-6357DiVA, id: diva2:979234
Note
Validerad; 2012; 20120816 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Basavoju, SrinivasVelaga, Sitaram

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