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Pharmaceutical salts of fluoroquinolone antibacterial drugs with acesulfame sweetener
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.
Energy Technology and Thermal Process Chemistry, Umeå University.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
2012 (engelsk)Inngår i: Molecular Crystals and Liquid Crystals, ISSN 1542-1406, E-ISSN 1563-5287, Vol. 562, nr 1, s. 254-264Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Novel organic salts of norfloxacin and ciprofloxacin with artificial sweeteners such as saccharin and acesulfame were prepared. The two salts 1 and 2 were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Finally, the crystal structures were solved by single crystal X-ray diffraction data and the structures were analyzed in terms of supramolecular synthons. In norfloxacin acesulfamate 1, two norfloxacin cations and two acesulfame anions form an eight membered cyclic tetramer supramolecular synthon. The salt, ciprofloxacin acesulfamate 2, has a similar structure as salt 1. This study contributes the importance of crystal engineering and supramolecular chemistry to the pharmaceutical applications in terms of interactions and structural correlations in the design of new solid phases. Supplemental materials are available for this article. Go to the publisher's online edition of Molecular Crystals and Liquid Crystals to view the free supplemental file

sted, utgiver, år, opplag, sider
2012. Vol. 562, nr 1, s. 254-264
HSV kategori
Forskningsprogram
Hälsovetenskap
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URN: urn:nbn:se:ltu:diva-6357DOI: 10.1080/10426507.2012.669673ISI: 000307059000022Scopus ID: 2-s2.0-84864705708Lokal ID: 496bb0cd-98fc-4d80-9c67-5066333af219OAI: oai:DiVA.org:ltu-6357DiVA, id: diva2:979234
Merknad
Validerad; 2012; 20120816 (andbra)Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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