Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Distribution of different fibre types in human skeletal muscles: a method for the detection of neurogenic disorders
Department of Statistics & Computational Mathematics, University of Liverpool.
Department of Statistics & Computational Mathematics, University of Liverpool.
Department of Neurology, Umeå university.
1987 (English)In: IMA journal of mathematics applied in medicine and biology, ISSN 0265-0746, E-ISSN 1471-6879, Vol. 4, no 1, p. 81-91Article in journal (Refereed) Published
Abstract [en]

Human skeletal muscles are composed of two distinguishable types of fibres, which in healthy muscles appear to be randomly arranged. Large groups of one fibre type are commonly regarded as evidence of a neuropathological process affecting the peripheral nerves or the nerve cells in the spinal cord. An objective method that detects non-random arrangements as a sign of a neurogenic disorder, particularly in its early stages, could improve diagnosis. The randomness, or otherwise, of the fibre type arrangement is here considered in terms of the numbers of fibres surrounded entirely by others of the same type (enclosed fibres). The distribution of the number of enclosed fibres is studied for a free-sampling model using Monte Carlo methods. The negative binomial distribution is shown to fit closely, where the parameters can be expressed in terms of the number of fibres and the fibre type proportion in a sample area. This result permits the calculation of significance levels for a sample area and the combination of information in several sample areas. Finally, the method is applied to whole cross-sections of 24 male human autopsied muscles.

Place, publisher, year, edition, pages
1987. Vol. 4, no 1, p. 81-91
Identifiers
URN: urn:nbn:se:ltu:diva-7962Local ID: 666fa280-a202-11de-8293-000ea68e967bOAI: oai:DiVA.org:ltu-7962DiVA, id: diva2:980852
Note
Upprättat; 1987; 20090915 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2017-11-24Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Lexell, Jan

Search in DiVA

By author/editor
Lexell, Jan
In the same journal
IMA journal of mathematics applied in medicine and biology

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf