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Influence of Alzheimer´s beta-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.ORCID iD: 0000-0002-6810-1882
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.ORCID iD: 0000-0003-1067-7990
2013 (English)In: Mendeleev communications (Print), ISSN 0959-9436, E-ISSN 1364-551X, Vol. 23, no 6, p. 316-318Article in journal (Refereed) Published
Abstract [en]

For the first time effect of added Alzheimer´s Abeta(1-40) peptide of wild type on lateral diffusion of lipids in macroscopically oriented bilayers of “raft” compositions (mixture of dioleoylphosphatidylcholine (DOPC), sphingomielin (SM) and cholesterol (CHOL)) was studied by NMR-diffusion technique. In homogeneous bilayers diffusion coefficients decrease, while in liquid ordered and in liquid disordered phases they change differently at varied concentrations of CHOL that was explained by decreased maximum solubility of CHOL in phospholipids in the presence of Abeta(1-40) peptide.

Place, publisher, year, edition, pages
2013. Vol. 23, no 6, p. 316-318
National Category
Physical Chemistry
Research subject
Chemistry of Interfaces
Identifiers
URN: urn:nbn:se:ltu:diva-8991DOI: 10.1016/j.mencom.2013.11.003ISI: 000328716400003Scopus ID: 2-s2.0-84888418522Local ID: 78c03ce3-1fcc-41c4-a859-818ca11dc2e1OAI: oai:DiVA.org:ltu-8991DiVA, id: diva2:981929
Note
Validerad; 2013; 20131107 (andfil)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Filippov, AndreiAntzutkin, Oleg

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