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Solubility of carbamazepine, nicotinamide and carbamazepine-nicotinamide cocrystal in ethanol-water mixtures
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
Drug Applied Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences.
2014 (Engelska)Ingår i: Fluid Phase Equilibria, ISSN 0378-3812, E-ISSN 1879-0224, Vol. 363, s. 97-105Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Solubility is an important physiochemical property of pharmaceutical compounds, and cocrystallization is one method used to improve the solubility of drugs. Carbamazepine is a drug from class II, according to the biopharmaceutical classification system, and it forms a cocrystal with nicotinamide. Carbamazepine cocrystallized with nicotinamide was synthesized using the solvent evaporation approach, and its characteristics were determined using differential scanning calorimetry and powder X-ray diffractometry. The solubility of various solid phases in ethanol. +. water mixtures was investigated at different temperatures using the shake-flask method, and the resulting precipitates were characterized. The solubility of carbamazepine was increased with the addition of ethanol up to a mass fraction of 0.8. Nevertheless, maximum solubility of NIC is observed in neat solvent (water). While the solubility of a cocrystal depends on the concentration of the coformer and its stability in the solution.

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2014. Vol. 363, s. 97-105
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URN: urn:nbn:se:ltu:diva-9896DOI: 10.1016/j.fluid.2013.11.024ISI: 000331494600013Scopus ID: 2-s2.0-84890205420Lokalt ID: 897da516-65a2-4a5b-9a18-21bba3c5a7fdOAI: oai:DiVA.org:ltu-9896DiVA, id: diva2:982835
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Validerad; 2014; 20140102 (andbra)Tillgänglig från: 2016-09-29 Skapad: 2016-09-29 Senast uppdaterad: 2018-07-10Bibliografiskt granskad

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