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Buccal Dosage Forms: general Considerations for Pediatric Patients
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago.ORCID iD: 0000-0002-3190-2168
Number of Authors: 32017 (English)In: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 18, no 2, p. 273-282Article in journal (Refereed) Published
Abstract [en]

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives. 

Place, publisher, year, edition, pages
Springer, 2017. Vol. 18, no 2, p. 273-282
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-11269DOI: 10.1208/s12249-016-0567-2ISI: 000396923200007PubMedID: 27301872Scopus ID: 2-s2.0-84974851810Local ID: a33184f4-38ce-482e-968d-1d8e6738d1e5OAI: oai:DiVA.org:ltu-11269DiVA, id: diva2:984218
Note

Validerad; 2017; Nivå 2; 2017-01-31 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-09-14Bibliographically approved

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Velaga, SitaramMorales, Javier O.

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