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Buccal Dosage Forms: general Considerations for Pediatric Patients
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, 8380494, Santiago.ORCID-id: 0000-0002-3190-2168
Rekke forfattare: 32017 (engelsk)Inngår i: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 18, nr 2, s. 273-282Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The development of an appropriate dosage form for pediatric patients needs to take into account several aspects, since adult drug biodistribution differs from that of pediatrics. In recent years, buccal administration has become an attractive route, having different dosage forms under development including tablets, lozenges, films, and solutions among others. Furthermore, the buccal epithelium can allow quick access to systemic circulation, which could be used for a rapid onset of action. For pediatric patients, dosage forms to be placed in the oral cavity have higher requirements for palatability to increase acceptance and therapy compliance. Therefore, an understanding of the excipients required and their functions and properties needs to be particularly addressed. This review is focused on the differences and requirements relevant to buccal administration for pediatric patients (compared to adults) and how novel dosage forms can be less invasive and more acceptable alternatives. 

sted, utgiver, år, opplag, sider
Springer, 2017. Vol. 18, nr 2, s. 273-282
HSV kategori
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Hälsovetenskap
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URN: urn:nbn:se:ltu:diva-11269DOI: 10.1208/s12249-016-0567-2ISI: 000396923200007PubMedID: 27301872Scopus ID: 2-s2.0-84974851810Lokal ID: a33184f4-38ce-482e-968d-1d8e6738d1e5OAI: oai:DiVA.org:ltu-11269DiVA, id: diva2:984218
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Validerad; 2017; Nivå 2; 2017-01-31 (andbra)

Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-09-14bibliografisk kontrollert

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