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Surface thermodynamics of mucoadhesive dry powder formulation of zolmitriptan
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-6050-0432
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.
University of Sassari.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
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2011 (English)In: AAPS PharmSciTech, ISSN 1530-9932, E-ISSN 1530-9932, Vol. 12, no 4, p. 1186-1192Article in journal (Refereed) Published
Abstract [en]

Microparticle powders for nasal delivery were formulated to contain the model drug, zolmitriptan, and varying proportions of different polymers. The objective of the study was to investigate the effects of these formulative parameters on the surface chemistry of the spray-dried microparticles and their potential for adhesion to the tested substrates, porcine mucin, and nasal tissue. The polymers used were chitosans of varying ionization states and molecular weights and hydroxypropyl methyl cellulose. The surface energies of the surfaces of the microparticles were determined using contact angle measurements and the van Oss model. The theory of surface thermodynamics was applied to determine the theoretical potential for the different materials to adhere to the substrates. It was found that the drug or polymers alone, as well as the various formulations, were more likely to adhere to mucin than to nasal tissue. Further, there was a trend for higher molecular weight chitosans to adhere better to the substrates than lower molecular weight chitosans. Similarly, adhesion was improved for formulations with a higher content of polymers. These theoretical predictions may be compared with further experimental results and be of use in making informed decisions on the choice of formulations for future expensive bio-studies.

Place, publisher, year, edition, pages
2011. Vol. 12, no 4, p. 1186-1192
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Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-11617DOI: 10.1208/s12249-011-9691-1ISI: 000297586500020PubMedID: 21918918Scopus ID: 2-s2.0-83555162608Local ID: aa0433de-a535-4200-a54c-74b8f0bcb5e4OAI: oai:DiVA.org:ltu-11617DiVA, id: diva2:984567
Note
Validerad; 2011; 20110926 (ysko)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Alhalaweh, AmjadVilinska, AnnamariaVelaga, Sitaram

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