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Two New Polymorphic Cocrystals of Zafirlukast: Preparation, Crystal Structure, and Stability Relations
R&D AstraZeneca, Respiratory, Inflammation and Autoimmune iMed.
Unitat de Polimorfisme i Calorimetria and Unitat de Difracció de Raigs X, Centres Científics i Tecnològics, Universitat de Barcelona.
Unitat de Polimorfisme i Calorimetria and Unitat de Difracció de Raigs X, Centres Científics i Tecnològics, Universitat de Barcelona.
R&D AstraZeneca, Global Medicines Development, Pharmaceutical Development.
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2015 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 15, no 8, p. 4162-4169Article in journal (Refereed) Published
Abstract [en]

Two new cocrystals of zafirlukast with piperazine, existing in five different solid forms, have been discovered during a cocrystal screening. The crystal structure of one of these form has been determined by single crystal X-ray diffraction, and the stability landscape of the crystalline forms of the new cocrystal has been studied. In the present article, we extend the knowledge about the solid state of this important pharmaceutical drug for the treatment of asthma by reporting the crystal structures of two new solvates (acetonitrile and butanol) and the elusive anhydrous Form X, which have been solved by single crystal X-ray diffraction

Place, publisher, year, edition, pages
2015. Vol. 15, no 8, p. 4162-4169
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Other Health Sciences
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Health Science
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URN: urn:nbn:se:ltu:diva-12863DOI: 10.1021/acs.cgd.5b00744ISI: 000359278800076Scopus ID: 2-s2.0-84938674763Local ID: c02f803d-b735-4863-b613-2f81ad78b824OAI: oai:DiVA.org:ltu-12863DiVA, id: diva2:985814
Note
Validerad; 2015; Nivå 2; 20150907 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Velaga, Sitaram

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