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Pharmaceutical cocrystal and salts of norfloxacin
Luleå University of Technology, Department of Health Sciences, Medical Science.
Energy Technology and Thermal Process Chemistry, Umeå University.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-0654-5410
2006 (English)In: Crystal Growth & Design, ISSN 1528-7483, E-ISSN 1528-7505, Vol. 6, no 12, p. 2699-2708Article in journal (Refereed) Published
Abstract [en]

The aim of this study was to investigate the structural and pharmaceutical properties of norfloxacin (a poorly soluble antibacterial drug), its cocrystal, and salts. Norfloxacin in the anhydrous form (form A, 1) was crystallized. It was cocrystallized with isonicotinamide (2), and organic salts were prepared with succinic acid, malonic acid, and maleic acid (3-5, respectively). These phases were characterized by differential scanning calorimetry (DSC), infrared (IR) and Raman spectroscopy, and powder X-ray diffraction (PXRD). Single-crystal X-ray diffraction data were obtained, and crystal structures were solved. The apparent solubility of these phases was determined. Robust O-H⋯O, O-H⋯O-, O-H⋯N, N-H⋯O, N+-H-O -, and N-H⋯N interactions were present in all these structures. Quinolone moieties in these structures stack with π⋯π interactions and form channels to include CHCl3 or H2O. Herein we report a new cocrystal and salts of norfloxacin with improved aqueous solubility

Place, publisher, year, edition, pages
2006. Vol. 6, no 12, p. 2699-2708
Identifiers
URN: urn:nbn:se:ltu:diva-14023DOI: 10.1021/cg060327xISI: 000242575100016Scopus ID: 2-s2.0-33846133535Local ID: d583a060-e8cb-11db-b9a9-000ea68e967bOAI: oai:DiVA.org:ltu-14023DiVA, id: diva2:986977
Note

Validerad; 2006; 20070412 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Basavoju, SrinivasVelaga, Sitaram

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