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Interaction of polyacrylic acid with lipid bilayers: effect of polymer mass
Kazan (Volga Region) Federal University, Kazan.
Kazan (Volga Region) Federal University, Kazan.
Kazan (Volga Region) Federal University, Kazan.
Luleå University of Technology, Department of Civil, Environmental and Natural Resources Engineering, Sustainable Process Engineering.ORCID iD: 0000-0003-1067-7990
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2013 (English)In: Magnetic Resonance in Chemistry, ISSN 0749-1581, E-ISSN 1097-458X, Vol. 51, no 11, p. 750-755Article in journal (Refereed) Published
Abstract [en]

Polyanion-coated lipid vesicles are proposed to have an appreciable potential for drug delivery because of their ability to control the permeability of lipid bilayers by environmental parameters such as pH and temperature. However, details of the interaction of this class of polymers with lipids and their mechanisms of induced permeability are still being debated. In this work, we applied 1H NOESY to study details of the interaction of polyacrylic acid (PAA) fractions of molecular weights 5 and 240 kDa with dimyristoylphosphatidylcholine vesicles. We showed that PAA of two different molecular masses modifies lipid bilayers increasing disorder and probability of close contact between polar and hydrophobic groups. PAA molecules adsorb near the interface of lipid bilayers but do not penetrate into the hydrophobic core of the bilayer and, thus, cannot participate in formation of transbilayer channels, proposed in earlier works. Increasing the molecular mass of PAA from 5 kDa to 240 kDa does not change the effect of PAA on the bilayer, although PAA240 forms a more compact structure (either intra-molecular or inter-molecular) and interacts more strongly with interface lipid protons

Place, publisher, year, edition, pages
2013. Vol. 51, no 11, p. 750-755
National Category
Physical Chemistry
Research subject
Chemistry of Interfaces
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URN: urn:nbn:se:ltu:diva-14785DOI: 10.1002/mrc.4013ISI: 000325262200011Scopus ID: 2-s2.0-84885130275Local ID: e356bc04-03f0-4942-ad21-aae930e9b6baOAI: oai:DiVA.org:ltu-14785DiVA, id: diva2:987758
Note
Validerad; 2013; 20130924 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Antzutkin, OlegFilippov, Andrei

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