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Serum SNTF Increases in Concussed Professional Ice Hockey Players and Relates to the Severity of Post-Concussion Symptoms
University of Pennsylvania School of Medicine, Neurosurgery.
Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0003-3628-0705
Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska Academy, University of Gothenburg, Mölndal.
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2015 (English)In: Journal of Neurotrauma, ISSN 0897-7151, E-ISSN 1557-9042, Vol. 32, no 17, p. 1294-1300Article in journal (Refereed) Published
Abstract [en]

Biomarkers for diffuse axonal injury could have utilities for the acute diagnosis and clinical care of concussion, including those related to sports. The calpain-derived alpha-spectrin N-terminal fragment SNTF accumulates in axons after traumatic injury, and increases in human blood following mild traumatic brain injury (mTBI) in relation to white matter abnormalities and persistent cognitive dysfunction. However, SNTF has never been evaluated as a biomarker for sports-related concussion. Here, we conducted longitudinal analysis of serum SNTF in professional ice hockey players, 28 of whom had a concussion, along with 45 players evaluated during the preseason, 17 of whom were also tested after a concussion-free training game. Compared to preseason levels, serum SNTF increased at 1 hour after concussion and remained significantly elevated from 12 hours to 6 days, before declining to preseason baseline. In contrast, serum SNTF levels were unchanged after training. In eight players, post-concussion symptoms resolved within a few days, and in these cases serum SNTF levels were at baseline. On the other hand, for the 20 players withheld from play for 6 days or longer, serum SNTF levels rose from 1 hour to 6 days post-concussion, and at 12-36 hours differed significantly from the less severe concussions (p=.004). Serum SNTF exhibited diagnostic accuracy for concussion, especially so with delayed return to play (AUC = 0.87). Multivariate analyses of serum SNTF and tau improved the diagnostic accuracy, the relationship with the delay in return to play, and the temporal window beyond tau alone. These results provide evidence that blood SNTF, a biomarker for axonal injury after mTBI, may be useful for diagnosis and prognosis of sports-related concussion, and for guiding neurobiologically-informed decisions on return to play

Place, publisher, year, edition, pages
2015. Vol. 32, no 17, p. 1294-1300
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Health Science
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URN: urn:nbn:se:ltu:diva-15234DOI: 10.1089/neu.2014.3698ISI: 000359564500002PubMedID: 25419578Scopus ID: 2-s2.0-84937986270Local ID: ebbffcaa-c818-4048-a148-c4bbcc94baffOAI: oai:DiVA.org:ltu-15234DiVA, id: diva2:988208
Note
Validerad; 2015; Nivå 2; 20150511 (andbra)Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2018-07-10Bibliographically approved

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Tegner, Yelverton

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