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Near-infrared spectroscopy for cocrystal screening: a comparative study with Raman spectroscopy
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, and Department of Food Science, Faculty of Life Sciences, University of Copenhagen.
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-0654-5410
Luleå tekniska universitet, Institutionen för hälsovetenskap, Medicinsk vetenskap.ORCID-id: 0000-0002-6050-0432
Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, and Department of Food Science, Faculty of Life Sciences, University of Copenhagen.
Vise andre og tillknytning
2008 (engelsk)Inngår i: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 80, nr 20, s. 7755-7764Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Near-infrared (NIR) spectroscopy is a well-established technique for solid-state analysis, providing fast, noninvasive measurements. The use of NIR spectroscopy for polymorph screening and the associated advantages have recently been demonstrated. The objective of this work was to evaluate the analytical potential of NIR spectroscopy for cocrystal screening using Raman spectroscopy as a comparative method. Indomethacin was used as the parent molecule, while saccharin and L-aspartic acid were chosen as guest molecules. Molar ratios of 1:1 for each system were subjected to two types of preparative methods. In the case of saccharin, liquid-assisted cogrinding as well as cocrystallization from solution resulted in a stable 1:1 cocrystalline phase termed IND-SAC cocrystal. For L-aspartic acid, the solution-based method resulted in a polymorphic transition of indomethacin into the metastable a form retained in a physical mixture with the guest molecule, while liquid-assisted cogrinding did not induce any changes in the crystal lattice. The good chemical peak selectivity of Raman spectroscopy allowed a straightforward interpretation of sample data by analyzing peak positions and comparing to those of pure references. In addition, Raman spectroscopy provided additional information on the crystal structure of the IND-SAC cocrystal. The broad spectral line shapes of NIR spectra make visual interpretation of the spectra difficult, and consequently, multivariate modeling by principal component analysis (PCA) was applied. Successful use of NIR/PCA was possible only through the inclusion of a set of reference mixtures of parent and guest molecules representing possible solid-state outcomes from the cocrystal screening. The practical hurdle related to the need for reference mixtures seems to restrict the applicability of NIR spectroscopy in cocrystal screening.

sted, utgiver, år, opplag, sider
2008. Vol. 80, nr 20, s. 7755-7764
Identifikatorer
URN: urn:nbn:se:ltu:diva-15646DOI: 10.1021/ac8011329ISI: 000259987800014Scopus ID: 2-s2.0-54349097469Lokal ID: f2fb7890-ab46-11dd-a7c5-000ea68e967bOAI: oai:DiVA.org:ltu-15646DiVA, id: diva2:988621
Merknad

Validerad; 2008; 20081105 (ysko)

Tilgjengelig fra: 2016-09-29 Laget: 2016-09-29 Sist oppdatert: 2018-07-10bibliografisk kontrollert

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