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Dual-modality probe intended for prostate cancer detection combining Raman spectroscopy and tactile resonance technology—discrimination of normal human prostate tissues ex vivo
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems. Centre for Biomedical Engineering and Physics (CMTF), Luleå, Umeå, Sweden.
Centre for Biomedical Engineering and Physics (CMTF), Luleå, Umeå, Sweden; Department of Applied Physics and Electronics, Umeå University, Umeå, Sweden.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Fluid and Experimental Mechanics. Centre for Biomedical Engineering and Physics (CMTF), Luleå, Umeå, Sweden.ORCID iD: 0000-0003-3268-1691
Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå Univeristy, Umeå, Sweden.
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2015 (English)In: Journal of Medical Engineering & Technology, ISSN 0309-1902, E-ISSN 1464-522X, Vol. 39, no 3, p. 198-207Article in journal (Refereed) Published
Abstract [en]

Prostate cancer is the most common cancer for men in the western world. For the first time, a dual-modality probe, combining Raman spectroscopy and tactile resonance technology, has been used for assessment of fresh human prostate tissue. The study investigates the potential of the dual-modality probe by testing its ability to differentiate prostate tissue types ex vivo. Measurements on four prostates show that the tactile resonance modality was able to discriminate soft epithelial tissue and stiff stroma (p < 0.05). The Raman spectra exhibited a strong fluorescent background at the current experimental settings. However, stroma could be discerned from epithelia by integrating the value of the spectral background. Combining both parameters by a stepwise analysis resulted in 100% sensitivity and 91% specificity. Although no cancer tissue was analysed, the results are promising for further development of the instrument and method for discriminating prostate tissues and cancer

Place, publisher, year, edition, pages
2015. Vol. 39, no 3, p. 198-207
National Category
Applied Mechanics
Research subject
Experimental Mechanics; Centre - Centre for Biomedical Engineering and Physics (CMTF)
Identifiers
URN: urn:nbn:se:ltu:diva-16285DOI: 10.3109/03091902.2015.1021430PubMedID: 25762203Scopus ID: 2-s2.0-84926353218Local ID: fe957028-5257-40a6-a492-377ef3d2879aOAI: oai:DiVA.org:ltu-16285DiVA, id: diva2:989261
Note

Validerad; 2015; Nivå 2; 20150316 (andbra)

Available from: 2016-09-29 Created: 2016-09-29 Last updated: 2024-03-26Bibliographically approved

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Nyberg, MorganRamser, KerstinLindahl, Olof

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