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Biological effects of wear particles generated in total joint replacements: trends and future prospects
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Machine Elements.
Institute of Medical and Biological Engineering, University of Leeds.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Machine Elements.ORCID iD: 0000-0001-8676-8819
2011 (English)Conference paper, Poster (with or without abstract) (Refereed)
Abstract [en]

Joint replacements have considerably improved the quality of life of patients with joints damaged by disease or trauma. However, problems associated with wear particles generated due to the relative motion between the components of the bearing are still present and can lead to the eventual failure of the implant. The biological response to wear debris is directly related to prosthesis longevity. The identification of the mechanisms by which cells respond to wear debris and how particles distribute around the human body may provide valuable information for the long term success of artificial joints.During the last few decades, orthopaedic research has been focused on predicting the in vivo performance of joint replacements. However, the exact interrelationship between material physicochemical properties and inflammatory response is not fully understood to date. Laboratory wear simulators provide an accurate prediction of implant wear performance. However, particles generated from such wear simulators require validation to compare them with particles extracted from peri-implant tissues. The present work focuses initially on the advantages and disadvantages of the different bearing combinations (hard-on-soft and hard-on-hard bearings). In addition, the similarities between particles observed in vivo and those generated in vitro to predict the cellular response to wear debris is discussed. Finally, the biological effects of the degradation products generated by wear and corrosion are described.

Place, publisher, year, edition, pages
2011.
National Category
Tribology (Interacting Surfaces including Friction, Lubrication and Wear)
Research subject
Machine Elements
Identifiers
URN: urn:nbn:se:ltu:diva-28208Local ID: 1ed79432-904d-4f1c-bb4f-fede40983abeOAI: oai:DiVA.org:ltu-28208DiVA, id: diva2:1001403
Conference
International Conference on BioTribology : 18/09/2011 - 21/09/2011
Note
Godkänd; 2011; 20111221 (emami)Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2018-03-08Bibliographically approved

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Moreno, Silvia SuñerEmami, Nazanin

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