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An experimental set-up for combining optical tweezers and laser scalpels with advanced imaging techniques
2003 (English)In: Microarrays and Combinatorial Technologies for Biomedical Applications: Design, Fabrication, and Analysis / [ed] Dan V. Nicolau; Ramesh Raghavachari, Bellingham, Wash: SPIE - International Society for Optical Engineering, 2003, p. 50-57Conference paper, Published paper (Refereed)
Abstract [en]

In this paper we will describe a system designed to combine optical tweezers and laser scalpels with confocal as well as epi-fluorescence microscopy. A continuos wave Nd:YVO4 laser is used to produce a dual optical tweezers, where each trap can be individually controlled. A second optical tweezers setup is based on a tunable titanium sapphire laser, which allows us to adjust the wavelength to minimize the damage to the cell under investigation. A pulsed nitrogen laser working at 337 nm forms a laser scalpel. The tweezers and scalpels are both incorporated in an inverted microscope equipped with epi-fluorescence and confocal imaging capabilities. In order to further control the sample we have developed a technique to tailor make the environment closest to the studied objects. Micrometer-sized structures such as channels and reservoirs have been produced in rubber silicon using lithographic methods. In combination with a micro-manipulator, our system can be used to extract single cells from a population of billions for further studies or growth.

Place, publisher, year, edition, pages
Bellingham, Wash: SPIE - International Society for Optical Engineering, 2003. p. 50-57
Series
Proceedings of the Society of Photo-Optical Instrumentation Engineers ; 4966
National Category
Other Medical Engineering
Research subject
Medical Engineering for Healthcare
Identifiers
URN: urn:nbn:se:ltu:diva-30381DOI: 10.1117/12.501010Local ID: 4296a7f0-cbf4-11db-b3ed-000ea68e967bISBN: 0-8194-4766-8 (print)OAI: oai:DiVA.org:ltu-30381DiVA, id: diva2:1003608
Conference
Microarrays and Combinatorial Technologies for Biomedical Applications : Design, Fabrication, and Analysis 26/01/2003 - 27/01/2003
Note
Upprättat; 2003; 20070306 (ysko)Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2017-11-25Bibliographically approved

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Ramser, Kerstin

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CiteExportLink to record
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Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
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