Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Utility of Hansen solubility parameters in the cocrystal screening
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Luleå University of Technology, Department of Health Sciences, Medical Science.ORCID iD: 0000-0002-6050-0432
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Damascus University, Department of Pharmaceutics and Pharmaceutical Technology, Facuöty of Pharmacology.
Show others and affiliations
2010 (English)In: Journal of Pharmacy and Pharmacology (JPP), ISSN 0022-3573, E-ISSN 2042-7158, Vol. 62, no 10 - Spec issue, p. 1360-1362Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

The objective of this study was to test if the miscibility between drug and coformer, as predicted by solubility parameters, can be used as a tool in the cocrystal research. Hansen Solubility Parameters (HSPs) of a model drug, indomethacin and thirty coformers were calculated according to the group contribution method. The distances in HSPs between indomethacin and each cocrystal former were then calculated using three validated miscibility tools. Twenty coformers were predicted and confirmed to be miscible with the drug. Interestingly, all cocrystals forming systems were miscible. Two new cocrystal systems were discovered through this approach. Therefore, the utility of the solubility parameters approach can enhance the effi ciency of cocrystal screening.

Place, publisher, year, edition, pages
2010. Vol. 62, no 10 - Spec issue, p. 1360-1362
National Category
Other Health Sciences
Research subject
Health Science
Identifiers
URN: urn:nbn:se:ltu:diva-38056Local ID: c52ffb80-cae2-11df-a707-000ea68e967bOAI: oai:DiVA.org:ltu-38056DiVA, id: diva2:1011555
Conference
UK Pharmsci Conference : 01/09/2010 - 03/09/2010
Note
Godkänd; 2010; 20100928 (ysko)Available from: 2016-10-03 Created: 2016-10-03 Last updated: 2018-05-31Bibliographically approved

Open Access in DiVA

No full text in DiVA

Authority records BETA

Alhalaweh, AmjadVelaga, Sitaram

Search in DiVA

By author/editor
Alhalaweh, AmjadVelaga, Sitaram
By organisation
Medical Science
In the same journal
Journal of Pharmacy and Pharmacology (JPP)
Other Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric score

urn-nbn
Total: 177 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf