The EU-sponsored VRUITS project has prioritized ITS applications which have a potential to improve the safety, mobility and comfort of vulnerable road users (VRUs) and performed a quantitative safety, mobility and comfort assessment for the 10 most promising systems. The assessment methodology addresses not only the direct effects of the systems, but also unintended effects and effects through changes in mobility patterns. The 10 selected ITS were: VRU beacon system, Powered Two Wheelers oncoming Vehicle information, Bicycle-to-vehicle communication, Cooperative Intersection safety, Green wave for cyclists, Pedestrian & Cyclist detection with Emergency Braking, Blind spot detection, Intelligent pedestrian traffic signal, Crossing adaptive lighting and Information on bike rack vacancy. The paper presents the quantitative estimates for the impact on safety, mobility and comfort. The outputs of the impact assessment are translated into socioeconomic indicators via a social cost-benefit analysis.