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Instrument towards faster diagnosis and treatment of prostate cancer: resonance sensor stiffness measurements on Human prostate tissue in vitro
Umeå University. Department of Applied Physics and Electronics.
Umeå University. Department of Applied Physics and Electronics.
Luleå University of Technology, Department of Computer Science, Electrical and Space Engineering, Signals and Systems.
2009 (English)In: World Congress on Medical Physics and Biomedical Engineering: September 7 - 12, 2009, Munich, Germany / [ed] Olaf Dössel; Wolfgang C. Schlegel, Berlin: Springer Science+Business Media B.V., 2009, 145-148 p.Conference paper (Refereed)
Abstract [en]

Prostate cancer is the most common cancer among men and the methods used to detect and diagnose prostate cancer are not sufficiently accurate. Radical prostatectomy is a surgical treatment of prostate cancer where the whole prostate is removed from the patient. Prostate tissue stiffness can be measured with a stiffness sensitive resonance sensor. The aim of this study was to measure the stiffness on the anterior and posterior side of fresh human prostate tissue in vitro and compare these two groups with each other and relate the findings with the prostate tissue histology. In a prostate tissue slice with mostly normal healthy tissue, the anterior side was significantly harder (p-value < 0.05) as expected. In a prostate tissue slice with areas of cancer tumors, no difference was found between the anterior and posterior sides. However, large stiffness variations were found within groups with measurements points on cancer tissue (coefficient of variation, CV = 42 and 85%), as opposed to groups without cancer tissue (CV = 27 and 28%). The large stiffness variations could be used as a sign for the presence of cancer. The results are promising for the development of an instrument and method for faster diagnosis on radical prostatectomy samples

Place, publisher, year, edition, pages
Berlin: Springer Science+Business Media B.V., 2009. 145-148 p.
Series
, International Federation for Medical and Biological Engineering Proceedings, ISSN 1680-0737 ; 25
Research subject
Medical Engineering for Healthcare
Identifiers
URN: urn:nbn:se:ltu:diva-39993Local ID: ef4397f0-add4-11de-8293-000ea68e967bOAI: oai:DiVA.org:ltu-39993DiVA: diva2:1013513
Conference
World Congress on Medical Physics and Biomedical Engineering : 07/09/2009 - 12/09/2009
Note
Validerad; 2009; 20090930 (olofl)Available from: 2016-10-03 Created: 2016-10-03Bibliographically approved

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