The aim of the study was to describe occupational therapy interventions for people with depression. The design for this study was a literature review based on a systematic selection of scientific papers which were analyzed and presented. The method was chosen to identify the current state of knowledge in the field. Data were collected through searching databases as well as through manual search. The articles were then examined for quality with 12 articles selected for the literature review. The articles were analyzed and resulted in two main categories: activity-based and structural-based interventions. They were then further categorised into four sub-headings: creative activities; work-oriented interventions; client consultation, training and courses; as well as intervention strategies to cope with everyday life and new ways of being. In summary, the results showed that occupational therapy interventions for people with depression contributes to increased self-confidence, promotes new strategies and ways of being and increased the sense of belonging and self-knowledge. The interventions resulted in a better structure to the client’s day, which led to increased activity, satisfaction whilst the symptoms of depression decreased in many of the studies. The results show a variety of interventions, with creative activities being the most frequent, but because the studies were of low quality the scientific evidence on the positive effects of the interventions were not proven. Although the studies had low evidence, they still have a great value from a client and treatment perspective.