Nanocellulose-Based Interpenetrating Polymer Network (IPN) Hydrogels for Cartilage Applications
Number of Authors: 5
2016 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 17, no 11, 3714–-3723 p.Article in journal (Refereed) Published
Double cross-linked interpenetrating polymer network (IPN) hydrogels of sodium alginate and gelatin (SA/G) reinforced with 50 wt % cellulose nanocrystals (CNC) have been prepared via the freeze-drying process. The IPNs were designed to incorporate CNC with carboxyl surface groups as a part of the network contribute to the structural integrity and mechanical stability of the hydrogel. Structural morphology studies of the hydrogels showed a three-dimensional (3D) network of interconnected pores with diameters in the range of 10-192 μm and hierarchical pores with a nanostructured pore wall roughness, which has potential benefits for cell adhesion. Significant improvements in the tensile strength and strain were achieved in 98% RH at 37 °C for CNC cross-linked IPNs. The high porosity of the scaffolds (>93%), high phosphate buffered saline (PBS) uptake, and cytocompatibility toward mesenchymal stem cells (MSCs) are confirmed and considered beneficial for use as a substitute for cartilage.
Place, publisher, year, edition, pages
2016. Vol. 17, no 11, 3714–-3723 p.
Research subject Wood and Bionanocomposites
IdentifiersURN: urn:nbn:se:ltu:diva-60205DOI: 10.1021/acs.biomac.6b01243PubMedID: 27726351ScopusID: 2-s2.0-84995527917OAI: oai:DiVA.org:ltu-60205DiVA: diva2:1045245
Validerad; 2016; Nivå 2; 2016-11-17 (andbra)2016-11-082016-11-082016-12-02Bibliographically approved