Ultra High Molecular Weight Polyethylene/Graphene Oxide Nanocomposites: Wear characterisation and Biological Response to wear particles
(English)Article in journal, News item (Refereed) Accepted
In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultra high molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of the present study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. The results showed that small amounts of GO nanoparticles (0.5 wt%) does not significantly alter the wear performance of UHMWPE. In contrast, the addition of larger amounts (2wt%) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not shown any adverse effect on L929 fibroblasts and PBMNC’s viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not affect the inflammatory cellular response to wear particles.
Total joint replacements, UHMWPE, graphene oxide, wear, cytotoxicity, TNF-α
Composite Science and Engineering
IdentifiersURN: urn:nbn:se:ltu:diva-60979OAI: oai:DiVA.org:ltu-60979DiVA: diva2:1054730