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Ultrahigh molecular weight polyethylene/graphene oxide nanocomposites: wear characterization and biological response to wear particles
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Machine Elements.
Institute of Medical and Biological Engineering, University of Leeds.
Institute of Medical and Biological Engineering, University of Leeds.
Luleå University of Technology, Department of Engineering Sciences and Mathematics, Machine Elements.
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Number of Authors: 6
2016 (English)In: Journal of Biomedical Materials Research. Part B - Applied biomaterials, ISSN 1552-4973, E-ISSN 1552-4981Article in journal (Refereed) Epub ahead of print
Abstract [en]

In the field of total joint replacements, polymer nanocomposites are being investigated as alternatives to ultrahigh molecular weight polyethylene (UHMWPE) for acetabular cup bearings. The objective of this study was to investigate the wear performance and biocompatibility of UHMWPE/graphene oxide (GO) nanocomposites. This study revealed that low concentrations of GO nanoparticles (0.5 wt %) do not significantly alter the wear performance of UHMWPE. In contrast, the addition of higher concentrations (2 wt %) led to a significant reduction in wear. In terms of biocompatibility, UHMWPE/GO wear particles did not show any adverse effects on L929 fibroblast and PBMNC viability at any of the concentrations tested over time. Moreover, the addition of GO to a UHMWPE matrix did not significantly affect the inflammatory response to wear particles. Further work is required to optimize the manufacturing processes to improve the mechanical properties of the nanocomposites and additional biocompatibility testing should be performed to understand the potential clinical application of these materials

Place, publisher, year, edition, pages
2016.
National Category
Tribology Composite Science and Engineering
Research subject
Machine Elements; Polymeric Composite Materials
Identifiers
URN: urn:nbn:se:ltu:diva-61091DOI: 10.1002/jbm.b.33821OAI: oai:DiVA.org:ltu-61091DiVA: diva2:1056788
Available from: 2016-12-15 Created: 2016-12-15 Last updated: 2016-12-15

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CiteExportLink to record
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Citation style
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